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Proceedings Article

Blue LED treatment of superficial abrasions

[+] Author Affiliations
Domenico Alfieri

Light4Tech Firenze S.r.l. (Italy)

Stefano Bacci, Gaetano De Siena, Virginia Lotti

Univ. degli Studi di Firenze (Italy)

Riccardo Cicchi

National Research Council (Italy)

Francesco Pavone

European Lab. for Non-linear Spectroscopy (Italy)

Roberto Pini, Francesca Rossi, Francesca Tatini

Istituto di Fisica Applicata Nello Carrara (Italy)

Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 85650H (March 8, 2013); doi:10.1117/12.2003933
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From Conference Volume 8565

  • Photonic Therapeutics and Diagnostics IX
  • Nikiforos Kollias; Bernard Choi; Haishan Zeng; Hyun Wook Kang; Bodo E. Knudsen; Brian J. Wong; Justus F. Ilgner; Melissa J. Suter; Stephen Lam; Matthew Brenner; Kenton W. Gregory; Guillermo J. Tearney; Laura Marcu; Henry Hirschberg; Steen J. Madsen; Anita Mahadevan-Jansen; E. Duco Jansen; Andreas Mandelis; Michael D. Morris
  • San Francisco, California, USA | February 02, 2013


A compact and easy-to-handle photocoagulation device was used for inducing an immediate coagulation effect in skin large superficial abrasions, reducing the recovering time and improving the wound healing process. The handheld illumination device consists of a high power LED, emitting in the blue region of the spectrum, mounted in a suitable and ergonomic case, together with power supply, electronics, and batteries. The working principle of the LED-based photocoagulator is a photothermal effect: the blue light is selectively absorbed by the haemoglobin content of the blood and then converted into heat. Here we present an in vivo study performed on animal models. 10 Sprague Dawley rats (Harlan, Italy, weighing 200-250 g) were used to study the wound healing process. On the back of each rat, four large abrasions were mechanically produced: two of them were used as a control, while the other two were treated with the photocoagulator, keeping it at a constant distance (2 mm) from the target, in continuous slow motion (treatment time: tens of seconds). The induced photothermal effect was monitored by an infrared thermocamera in order to avoid accidental thermal damage and to control the temperature dynamics during treatment. Objective observations, histopathological analysis and non-linear microscopy performed in a 8 days follow-up study showed no adverse reactions and no thermal damage in the treated areas and surrounding tissues. Moreover, a faster healing process and a better recovered morphology was evidenced in the treated tissue. © (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.

Domenico Alfieri ; Stefano Bacci ; Riccardo Cicchi ; Gaetano De Siena ; Virginia Lotti, et al.
" Blue LED treatment of superficial abrasions ", Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 85650H (March 8, 2013); doi:10.1117/12.2003933; http://dx.doi.org/10.1117/12.2003933

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