A time-gated near-infrared spectroscopic imaging device for clinical applications.

Patrick Poulet; Wilfried Uhring; Walter Hanselmann; René Glazenborg; Farouk Nouizi; Virginie Zint; Werner Hirschi

doi:10.1117/12.2003671

8 March 2013 A time-gated near-infrared spectroscopic imaging device for clinical applications.

Patrick Poulet, Wilfried Uhring, Walter Hanselmann, René Glazenborg, Farouk Nouizi, Virginie Zint, Werner Hirschi

Proceedings Volume 8565, Photonic Therapeutics and Diagnostics IX; 85654M (2013) https://doi.org/10.1117/12.2003671
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

A time-resolved, spectroscopic, diffuse optical tomography device was assembled for clinical applications like brain functional imaging. The entire instrument lies in a unique setup that includes a light source, an ultrafast time-gated intensified camera and all the electronic control units. The light source is composed of four near infrared laser diodes driven by a nanosecond electrical pulse generator working in a sequential mode at a repetition rate of 100 MHz. The light pulses are less than 80 ps FWHM. They are injected in a four-furcated optical fiber ended with a frontal light distributor to obtain a uniform illumination spot directed towards the head of the patient. Photons back-scattered by the subject are detected by the intensified CCD camera. There are resolved according to their time of flight inside the head. The photocathode is powered by an ultrafast generator producing 50 V pulses, at 100 MHz and a width corresponding to a 200 ps FWHM gate. The intensifier has been specially designed for this application. The whole instrument is controlled by an FPGA based module. All the acquisition parameters are configurable via software through an USB plug and the image data are transferred to a PC via an Ethernet link. The compactness of the device makes it a perfect device for bedside clinical applications. The instrument will be described and characterized. Preliminary data recorded on test samples will be presented.

Citation Download Citation

Patrick Poulet, Wilfried Uhring, Walter Hanselmann, René Glazenborg, Farouk Nouizi, Virginie Zint, and Werner Hirschi "A time-gated near-infrared spectroscopic imaging device for clinical applications.", Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 85654M (8 March 2013); https://doi.org/10.1117/12.2003671

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