Low level light therapy (LLLT) has been widely reported to reduce pain and inflammation
and enhance wound healing and tissue regeneration in various settings. LLLT has been noted to have
both stimulatory and inhibitory biological effects and these effects have been termed
Photobiomodulation (PBM). Several elegant studies have shown the key role of Cytochrome C
oxidase and ROS in initiating this process. The downstream biological responses remain to be
clearly elucidated. Our work has demonstrated activation of an endogenous latent growth factor
complex, TGF-β1, as one of the major biological events in PBM. TGF-β1 has critical roles in
various biological processes especially in inflammation, immune responses, wound healing and stem
cell biology. This paper overviews some of the studies demonstrating the efficacy of PBM in
promoting tissue regeneration.
© (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Elieza G. Tang and Praveen R. Arany
Tissue regeneration with photobiomodulation
", Proc. SPIE 8569, Mechanisms for Low-Light Therapy VIII, 856907 (March 5, 2013); doi:10.1117/12.2019284; http://dx.doi.org/10.1117/12.2019284