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Proceedings Article

Tissue regeneration with photobiomodulation

[+] Author Affiliations
Elieza G. Tang, Praveen R. Arany

National Institute of Dental and Craniofacial Research (United States)

Proc. SPIE 8569, Mechanisms for Low-Light Therapy VIII, 856907 (March 5, 2013); doi:10.1117/12.2019284
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From Conference Volume 8569

  • Mechanisms for Low-Light Therapy VIII
  • Michael R. Hamblin; James D. Carroll; Praveen R. Arany
  • San Francisco, California, USA | February 02, 2013


Low level light therapy (LLLT) has been widely reported to reduce pain and inflammation and enhance wound healing and tissue regeneration in various settings. LLLT has been noted to have both stimulatory and inhibitory biological effects and these effects have been termed Photobiomodulation (PBM). Several elegant studies have shown the key role of Cytochrome C oxidase and ROS in initiating this process. The downstream biological responses remain to be clearly elucidated. Our work has demonstrated activation of an endogenous latent growth factor complex, TGF-β1, as one of the major biological events in PBM. TGF-β1 has critical roles in various biological processes especially in inflammation, immune responses, wound healing and stem cell biology. This paper overviews some of the studies demonstrating the efficacy of PBM in promoting tissue regeneration. © (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.

Elieza G. Tang and Praveen R. Arany
" Tissue regeneration with photobiomodulation ", Proc. SPIE 8569, Mechanisms for Low-Light Therapy VIII, 856907 (March 5, 2013); doi:10.1117/12.2019284; http://dx.doi.org/10.1117/12.2019284

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