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Proceedings Article

Noninvasive imaging of absolute PpIX concentration distribution in nonmelanoma skin tumors at pre-PDT

[+] Author Affiliations
Ulas Sunar, Daniel Rohrbach, Janet Morgan, Natalie Zeitouni

Roswell Park Cancer Institute (United States)

Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 85680C (March 13, 2013); doi:10.1117/12.2005078
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From Conference Volume 8568

  • Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII
  • David H. Kessel; Tayyaba Hasan
  • San Francisco, California, USA | February 02, 2013

abstract

Photodynamic Therapy (PDT) has proven to be an effective treatment option for nonmelanoma skin cancers. The ability to quantify the concentration of drug in the treated area is crucial for effective treatment planning as well as predicting outcomes. We utilized spatial frequency domain imaging for quantifying the accurate concentration of protoporphyrin IX (PpIX) in phantoms and in vivo. We correct fluorescence against the effects of native tissue absorption and scattering parameters. First we quantified the absorption and scattering of the tissue non-invasively. Then, we corrected raw fluorescence signal by compensating for optical properties to get the absolute drug concentration. After phantom experiments, we used basal cell carcinoma (BCC) model in Gli mice to determine optical properties and drug concentration in vivo at pre-PDT. © (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Ulas Sunar ; Daniel Rohrbach ; Janet Morgan and Natalie Zeitouni
" Noninvasive imaging of absolute PpIX concentration distribution in nonmelanoma skin tumors at pre-PDT ", Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 85680C (March 13, 2013); doi:10.1117/12.2005078; http://dx.doi.org/10.1117/12.2005078


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