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Proceedings Article

A probe specific empirical light transport model for improved quantification of optical parameters for accurate PDT dosimetry

[+] Author Affiliations
Daniel J. Rohrbach, Andrew Kowalczewski, Bouri Chen, Ulas Sunar

Roswell Park Cancer Institute (United States)

Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 856815 (March 13, 2013); doi:10.1117/12.2005051
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From Conference Volume 8568

  • Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII
  • David H. Kessel; Tayyaba Hasan
  • San Francisco, California, USA | February 02, 2013

abstract

Diffuse reflectance spectroscopy (DRS) is a common technique for assessing tissue optical parameters (absorption, scattering) non-invasively. However, choosing the correct model for light-tissue interaction is needed for accurate quantification. The diffusion approximation is only valid for certain ranges of tissue optical properties and specific probe geometries. For improved quantification with DRS over a wide range of optical properties and for a short source detector separation, a probe-specific light transport model can provide more accurate analysis of optical parameters. We developed and tested a probe-specific empirical model by using tissue simulating phantoms with promising results. We will apply it for the analysis of patients from a clinical trial for head and neck cancer. © (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Daniel J. Rohrbach ; Andrew Kowalczewski ; Bouri Chen and Ulas Sunar
" A probe specific empirical light transport model for improved quantification of optical parameters for accurate PDT dosimetry ", Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 856815 (March 13, 2013); doi:10.1117/12.2005051; http://dx.doi.org/10.1117/12.2005051


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