Calculation of singlet oxygen formation from one photon absorbing photosensitizers used in PDT

M. Potasek; Evgueni Parilov; K. Beeson

doi:10.1117/12.2003133

13 March 2013 Calculation of singlet oxygen formation from one photon absorbing photosensitizers used in PDT

M. Potasek, Evgueni Parilov, K. Beeson

Proceedings Volume 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII; 85681D (2013) https://doi.org/10.1117/12.2003133
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Advances in biophotonic medicine require new information on photodynamic mechanisms. In photodynamic therapy (PDT), a photosensitizer (PS) is injected into the body and accumulates at higher concentrations in diseased tissue compared to normal tissue. The PS absorbs light from a light source and generates excited-state triplet states of the PS. The excited triplet states of the PS can then react with ground state molecular oxygen to form excited singlet - state oxygen or form other highly reactive species. The reactive species react with living cells, resulting in cel l death. This treatment is used in many forms of cancer including those in the prostrate, head and neck, lungs, bladder, esophagus and certain skin cancers. We developed a novel numerical method to model the photophysical and photochemical processes in the PS and the subsequent energy transfer to O₂, improving the understanding of these processes at a molecular level. Our numerical method simulates light propagation and photo-physics in PS using methods that build on techniques previously developed for optical communications and nonlinear optics applications.

Citation Download Citation

M. Potasek, Evgueni Parilov, and K. Beeson "Calculation of singlet oxygen formation from one photon absorbing photosensitizers used in PDT", Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 85681D (13 March 2013); https://doi.org/10.1117/12.2003133

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