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Proceedings Article

Calculation of singlet oxygen formation from one photon absorbing photosensitizers used in PDT

[+] Author Affiliations
M. Potasek, Evgueni Parilov, K. Beeson

Simphotek, Inc. (United States)

Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 85681D (March 13, 2013); doi:10.1117/12.2003133
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From Conference Volume 8568

  • Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII
  • David H. Kessel; Tayyaba Hasan
  • San Francisco, California, USA | February 02, 2013

abstract

Advances in biophotonic medicine require new information on photodynamic mechanisms. In photodynamic therapy (PDT), a photosensitizer (PS) is injected into the body and accumulates at higher concentrations in diseased tissue compared to normal tissue. The PS absorbs light from a light source and generates excited-state triplet states of the PS. The excited triplet states of the PS can then react with ground state molecular oxygen to form excited singlet - state oxygen or form other highly reactive species. The reactive species react with living cells, resulting in cel l death. This treatment is used in many forms of cancer including those in the prostrate, head and neck, lungs, bladder, esophagus and certain skin cancers. We developed a novel numerical method to model the photophysical and photochemical processes in the PS and the subsequent energy transfer to O2, improving the understanding of these processes at a molecular level. Our numerical method simulates light propagation and photo-physics in PS using methods that build on techniques previously developed for optical communications and nonlinear optics applications. © (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

M. Potasek ; Evgueni Parilov and K. Beeson
" Calculation of singlet oxygen formation from one photon absorbing photosensitizers used in PDT ", Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 85681D (March 13, 2013); doi:10.1117/12.2003133; http://dx.doi.org/10.1117/12.2003133


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