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Proceedings Article

Energy dispersive X-ray diffraction computed tomography of breast-simulating phantoms and a tissue sample

[+] Author Affiliations
Shyma M. Alkhateeb, Mohamed H. Abdelkader, David A. Bradley, Silvia Pani

Univ. of Surrey (United Kingdom)

Paul Seller, Matthew C. Veale, Matt D. Wilson

Rutherford Appleton Lab. (United Kingdom)

Proc. SPIE 8668, Medical Imaging 2013: Physics of Medical Imaging, 86684G (March 19, 2013); doi:10.1117/12.2007710
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From Conference Volume 8668

  • Medical Imaging 2013: Physics of Medical Imaging
  • Robert M. Nishikawa; Bruce R. Whiting
  • Lake Buena Vista (Orlando Area), Florida, USA | February 09, 2013

abstract

Breast lesions and normal tissue have different characteristics of density and molecular arrangement that affect their diffraction patterns. X-ray diffraction can be used to determine the spatial structure of such tissues at the atomic and molecular level and Energy Dispersive X-Ray Diffraction Computed Tomography (EDXRDCT) can be used to produce 2-dimensional images of cross sections of the samples. The purpose of this work is to use an EDXRDCT system to find the limiting visibility for details that simulate breast lesions. Results are presented for EDXRDCT images of samples of different materials simulating breast tissue contrast and shapes. For simple circular details, the contrast between details and background in the images was measured with the goal of simulating the contrast between real breast tissue components. The limiting visible diameter was measured as a function of detail diameter for different combinations of scanning and geometrical parameters. Images of more complex test objects were assessed in terms of both contrast and accuracy of shape reproduction, evaluating the feasibility of using shape analysis as an additional parameter for lesion identification. The optimum combination of parameters are intended to be applied to the scanning of waxed breast tissue blocks. © (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Shyma M. Alkhateeb ; Mohamed H. Abdelkader ; David A. Bradley ; Paul Seller ; Matthew C. Veale, et al.
" Energy dispersive X-ray diffraction computed tomography of breast-simulating phantoms and a tissue sample ", Proc. SPIE 8668, Medical Imaging 2013: Physics of Medical Imaging, 86684G (March 19, 2013); doi:10.1117/12.2007710; http://dx.doi.org/10.1117/12.2007710


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