Monitoring of cycling hypoxia and angiogenesis in FaDu head and neck tumors using a side-firing sensor

Bing Yu; Amy Shah; Bingqing Wang; Narasimhan Rajaram; Quanli Wang; Nirmala Ramanujam; Gregory M. Palmer; Mark W. Dewhirst

doi:10.1117/12.2002837

25 March 2013 Monitoring of cycling hypoxia and angiogenesis in FaDu head and neck tumors using a side-firing sensor

Bing Yu, Amy Shah, Bingqing Wang, Narasimhan Rajaram, Quanli Wang, Nirmala Ramanujam, Gregory M. Palmer, Mark W. Dewhirst

Author Affiliations +

Proceedings Volume 8578, Optical Tomography and Spectroscopy of Tissue X; 85781E (2013) https://doi.org/10.1117/12.2002837
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Many studies have found that hypoxia, particularly cycling hypoxia (CH), can lead to enhanced tumor metastasis and resistance to radiation and chemotherapy. It was also reported that tumor total hemoglobin content (THb), which is directly related to tumor angiogenesis, can have significant impact on tumor’s response to radiation and neoadjuvant chemotherapy. There is a growing demand for technologies to measure tumor hypoxia and angiogenesis temporally in vivo. In this paper, a side-firing fiber optic sensor based on a multi-wavelength frequency-domain near infrared spectroscopy (FD-NIRS) instrument was used to quantify tumor oxygenation and hemoglobin concentrations in nude rats bearing human FaDu head and neck (H and N) tumors during normoxia and forced hyperoxia and cyclic hypoxia. Significant increase (with carbogen gas inhalation) or decrease (with reduced O₂ supply) in tumor oxygenation was observed. The studies demonstrated the feasibility of the technology for longitudinal monitoring of H and N tumor’s response to therapy.

Citation Download Citation

Bing Yu, Amy Shah, Bingqing Wang, Narasimhan Rajaram, Quanli Wang, Nirmala Ramanujam, Gregory M. Palmer, and Mark W. Dewhirst "Monitoring of cycling hypoxia and angiogenesis in FaDu head and neck tumors using a side-firing sensor", Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85781E (25 March 2013); https://doi.org/10.1117/12.2002837

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