Development of transrectal diffuse optical tomography combined with 3D-transrectal ultrasound imaging to monitor the photocoagulation front during interstitial photothermal therapy of primary focal prostate cancer

Jie He; Robert Weersink; Israel Veilleux; Kenwrick Mayo; Anqi Zhang; Daqing Piao; Adeel Alam; John Trachtenberg; Brian C. Wilson

doi:10.1117/12.2004457

25 March 2013 Development of transrectal diffuse optical tomography combined with 3D-transrectal ultrasound imaging to monitor the photocoagulation front during interstitial photothermal therapy of primary focal prostate cancer

Jie He, Robert Weersink, Israel Veilleux, Kenwrick Mayo, Anqi Zhang, Daqing Piao, Adeel Alam, John Trachtenberg, Brian C. Wilson

Author Affiliations +

Proceedings Volume 8578, Optical Tomography and Spectroscopy of Tissue X; 85781J (2013) https://doi.org/10.1117/12.2004457
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Interstitial near-infrared laser thermal therapy (LITT) is currently undergoing clinical trials as an alternative to watchful waiting or radical surgery in patients with low-risk focal prostate cancer. Currently, we use magnetic resonance image (MRI)-based thermography to monitor treatment delivery and determine indirectly the completeness of the target tissue destruction while avoiding damage to adjacent normal tissues, particularly the rectal wall. However, incomplete tumor destruction has occurred in a significant fraction of patients due to premature termination of treatment, since the photocoagulation zone is not directly observed. Hence, we are developing transrectal diffuse optical tomography (TRDOT), in combination with transrectal 3D ultrasound (3D-TRUS), to address his limitation. This is based on the large changes in optical scattering expected upon tissue coagulation. Here, we present forward simulations of a growing coagulated lesion with optical scattering contrast, using an established finite element analysis software platform (NIRFAST). The simulations were validated in tissue-simulating phantoms, with measurements acquired by a state-of-the-art continuous wave (CW) TRDOT system and a recently assembled bench-top CW-DOT system, with specific source-detector configurations. Two image reconstruction schemes were investigated and evaluated, specifically for the accurate delineation of the posterior boundary of the coagulation zone as the critical parameter for treatment guidance in this clinical application.

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Jie He, Robert Weersink, Israel Veilleux, Kenwrick Mayo, Anqi Zhang, Daqing Piao, Adeel Alam, John Trachtenberg, and Brian C. Wilson "Development of transrectal diffuse optical tomography combined with 3D-transrectal ultrasound imaging to monitor the photocoagulation front during interstitial photothermal therapy of primary focal prostate cancer", Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85781J (25 March 2013); https://doi.org/10.1117/12.2004457

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