Proceedings Article

Breast imaging with the SoftVue imaging system: first results

[+] Author Affiliations
Neb Duric, Peter Littrup, Steven Schmidt, Cuiping Li, Olivier Roy, Lisa Bey-Knight

Karmanos Cancer Institute (United States)

Roman Janer, Dave Kunz, Xiaoyang Chen, Jeffrey Goll, Andrea Wallen, Fouzaan Zafar, Veerendra Allada, Erik West, Ivana Jovanovic, Kuo Li, William Greenway

Delphinus Medical Technologies, Inc. (United States)

Proc. SPIE 8675, Medical Imaging 2013: Ultrasonic Imaging, Tomography, and Therapy, 86750K (March 29, 2013); doi:10.1117/12.2002513
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Open Access

From Conference Volume 8675

  • Medical Imaging 2013: Ultrasonic Imaging, Tomography, and Therapy
  • Johan G. Bosch; Marvin M. Doyley
  • Lake Buena Vista (Orlando Area), Florida, USA | February 09, 2013

abstract

For women with dense breast tissue, who are at much higher risk for developing breast cancer, the performance of mammography is at its worst. Consequently, many early cancers go undetected when they are the most treatable. Improved cancer detection for women with dense breasts would decrease the proportion of breast cancers diagnosed at later stages, which would significantly lower the mortality rate. The emergence of whole breast ultrasound provides good performance for women with dense breast tissue, and may eliminate the current trade-off between the cost effectiveness of mammography and the imaging performance of more expensive systems such as magnetic resonance imaging. We report on the performance of SoftVue, a whole breast ultrasound imaging system, based on the principles of ultrasound tomography. SoftVue was developed by Delphinus Medical Technologies and builds on an early prototype developed at the Karmanos Cancer Institute. We present results from preliminary testing of the SoftVue system, performed both in the lab and in the clinic. These tests aimed to validate the expected improvements in image performance. Initial qualitative analyses showed major improvements in image quality, thereby validating the new imaging system design. Specifically, SoftVue’s imaging performance was consistent across all breast density categories and had much better resolution and contrast. The implications of these results for clinical breast imaging are discussed and future work is described. © (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.

references

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American Cancer Society. Cancer Prevention & Early Detection Facts & Figures 2009. Atlanta, GA: American Cancer Society, 2009; 34-37. Boyd NF, Guo H, Martin LJ, Sun L, Stone J, Fishell E, Jong RA, Hislop G, Chiarelli
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Armstrong K, Moye E, Williams S, Berlin JA, Reynolds EE. Screening mammography in women 40 to 49 years of age: a systematic review for the American College of Physicians. Ann Intern Med. 2007; 146:516-26
A, Minkin S. et al.: Mammographic density and the risk and detection of breast cancer. N Engl J Med 2007, 356:227-236.
Turnbull, LW. Dynamic contrast-enhanced MRI in the diagnosis and management of breast cancer. J NMR Biomed 2008.
Jansen, SA,Fan, X, Karczmar, GS, Abe, H, Schmidt, RA, Newstead, GM. Differentiation between benign and malignant breast lesions detected by bilateral dynamic contrast-enhanced MRI: A sensitivity and specificity study. MAGNETIC RESONANCE IN MEDICINE. 59, 4, 747, 2008. John Wiley & Sons, Ltd
Kuhl CK, Schrading S, Bieling HB, Wardelmann E, Leutner CC, Koenig R, Kuhn W, Schild HH. MRI for diagnosis of pure ductal carcinoma in situ: a prospective observational study. Lancet. 2007; 370:485-92.
Saslow D, Boetes C, Burke W, Harms S, Leach MO, Lehman CD, Morris E, Pisano E, Schnall M, Sener S, Smith RA, Warner E, Yaffe M, Andrews KS, Russell CA; American Cancer Society Breast Cancer Advisory Group. American Cancer Society guidelines for breast screening with MRI as an adjunct to mammography. CA Cancer J Clin. 2007; 57:75-89.
Chen, J.H., et al., MRI evaluation of pathologically complete response and residual tumors in breast cancer after neoadjuvant chemotherapy. Cancer, 2008. 112(1): p. 17-26.
Sharma, U., et al., Longitudinal study of the assessment by MRI and diffusion-weighted imaging of tumor response in patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy. NMR Biomed, 2009. 22(1): p. 104-13.
Bando, H., et al., Imaging evaluation of pathological response in breast cancer after neoadjuvant chemotherapy by real-time sonoelastography and MRI. European Journal of Cancer-Supplement, 2008. 6(7): p. 66-66.
Bhattacharyya, M., et al., Using MRI to plan breast-conserving surgery following neoadjuvant chemotherapy for early breast cancer. Br J Cancer, 2008. 98(2): p. 289-93.
Partridge, S., Recurrence Rates After DCE-MRI Image Guided Planning for Breast-conserving Surgery Following Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer Patients. Breast Diseases: A Year Book Quarterly, 2008. 19(1): p. 91-91.
Tozaki, M., Diagnosis of breast cancer: MDCT versus MRI. Breast Cancer, 2008. 15(3): p. 205-211.
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Berg WA, Blume JD, Cormack JB, Mendelson EB, Lehrer D, Böhm-Vélez M, Pisano ED, Jong RA, Evans WP, Morton MJ, Mahoney MC, Hovanessian Larsen L, Barr RG, Farria DM, Marques HS, Boparai K, for the ACRIN 6666 Investigators. Combined Screening With Ultrasound and Mammography vs Mammography Alone in Women at Elevated Risk of Breast Cancer. JAMA 2008;299(18):2151-2163.
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Andre MP, Janee HS, Martin PJ, Otto GP, Spivey BA, Palmer DA, "High-speed data acquisition in a diffraction tomography system employing large-scale toroidal arrays," International Journal of Imaging Systems and Technology 1997;Vol. 8, Issue 1:137-147.
Johnson SA, Borup DT, Wiskin JW, Natterer F, Wuebbling F, Zhang Y, Olsen C. Apparatus and Method for Imaging with Wavefields using Inverse Scattering Techniques. United States Patent 6,005,916 (1999).
Marmarelis VZ, Kim T, Shehada RE. Proceedings of the SPIE: Medical Imaging; Ultrasonic Imaging and Signal Processing 2003, Paper 5035-6.
Liu D-L, Waag RC. "Propagation and backpropagation for ultrasonic wavefront design," IEEE Trans. on Ultras. Ferro. and Freq. Contr. 1997;44(1):1-13.
Gemmeke, H and Ruiter, N. "3D ultrasound computer tomography for medical imaging". Nuclear instruments and methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol. 580, no. 2, pp 1057-1065, 2007.
Nicole V. Ruiter, Georg Göbel, Lutz Berger, Michael Zapf and Hartmut Gemmeke, "Realization of an optimized 3D USCT", Proc. SPIE 7968, 796805 (2011)
Duric N, Littrup P, Poulo L, Babkin A, Pevzner R, Holsapple E, Rama O, Glide C. Detection of Breast Cancer With Ultrasound Tomography: First Results with the Computerized Ultrasound Risk Evaluation (C.U.R.E) Prototype. Medical Physics Feb 2007; Vol 34 (2), pp. 773-785.
Glide CK, Duric N. Littrup P. A new method for quantitative analysis of mammographic density. Med Phys. 2007 Nov; Vol. 34, Issue 11:4491-4498.
Glide-Hurst C, Duric N, Littrup P. Volumetric breast density evaluation from ultrasound tomography images. Med Phys. 2008;Vol. 35, Issue 9, pp. 3988-3997.
Duric N, Li C, Littrup PJ, Huang L, Glide-Hurst C, Rama O, Bey-Knight L, Schmidt S, Xu Y, Lupinacci J. Detection and characterization of breast masses with ultrasound tomography: clinical results. Proc. SPIE 2008; 6920, 6920-28.
Li C, Duric N, Huang LJ. Clinical breast imaging using sound-speed reconstructions of ultrasound tomography data. Proc. SPIE 2008;6920, 6920-09.
Ranger B, Littrup P, Duric N, Chandiwala-Mody P, Li C, Schmidt S and Lupinacci J. Breast ultrasound tomography versus magnetic resonance imaging for clinical display of anatomy and tumor rendering: Preliminary results. AJR Am J Roentgenol Jan 2012; 198(1):233-9.
Lupinacci J, Duric N, Li C, Littrup P, Wang D, Rama O, Schmidt S. Monitoring of breast masses with ultrasound tomography for patients undergoing neoadjuvant chemotherapy. Proc. SPIE 2009;7265, 7265-43.
Full text of this article:
Citation

Neb Duric ; Peter Littrup ; Steven Schmidt ; Cuiping Li ; Olivier Roy ; Lisa Bey-Knight ; Roman Janer ; Dave Kunz ; Xiaoyang Chen ; Jeffrey Goll ; Andrea Wallen ; Fouzaan Zafar ; Veerendra Allada ; Erik West ; Ivana Jovanovic ; Kuo Li and William Greenway
" Breast imaging with the SoftVue imaging system: first results ", Proc. SPIE 8675, Medical Imaging 2013: Ultrasonic Imaging, Tomography, and Therapy, 86750K (March 29, 2013); doi:10.1117/12.2002513; http://dx.doi.org/10.1117/12.2002513


Figures

Tables

SEER website. http://seer.cancer.gov/
American Cancer Society. Cancer Prevention & Early Detection Facts & Figures 2009. Atlanta, GA: American Cancer Society, 2009; 34-37. Boyd NF, Guo H, Martin LJ, Sun L, Stone J, Fishell E, Jong RA, Hislop G, Chiarelli
Chen J, Pee D, Ayyagari R, Graubard B, Schairer C, Byrne C, Benichou J, Gail MH: Projecting absolute invasive breast cancer risk in white women with a model that includes mammographic density. J Natl Cancer Inst 2006, 98:1215-1226.
Ursin G, Hovanessian-Larsen L, Parisky YR, Pike MC, Wu AH: Greatly increased occurrence of breast cancers in areas of mammographically dense tissue. Breast Cancer Res 2005, 7:R605-R608.
Martin LJ, Boyd N: Potential mechanisms of breast cancer risk associated with mammographic density: hypotheses based on epidemiological evidence. Breast Cancer Res 2008, 10:1-14.
Armstrong K, Moye E, Williams S, Berlin JA, Reynolds EE. Screening mammography in women 40 to 49 years of age: a systematic review for the American College of Physicians. Ann Intern Med. 2007; 146:516-26
A, Minkin S. et al.: Mammographic density and the risk and detection of breast cancer. N Engl J Med 2007, 356:227-236.
Turnbull, LW. Dynamic contrast-enhanced MRI in the diagnosis and management of breast cancer. J NMR Biomed 2008.
Jansen, SA,Fan, X, Karczmar, GS, Abe, H, Schmidt, RA, Newstead, GM. Differentiation between benign and malignant breast lesions detected by bilateral dynamic contrast-enhanced MRI: A sensitivity and specificity study. MAGNETIC RESONANCE IN MEDICINE. 59, 4, 747, 2008. John Wiley & Sons, Ltd
Kuhl CK, Schrading S, Bieling HB, Wardelmann E, Leutner CC, Koenig R, Kuhn W, Schild HH. MRI for diagnosis of pure ductal carcinoma in situ: a prospective observational study. Lancet. 2007; 370:485-92.
Saslow D, Boetes C, Burke W, Harms S, Leach MO, Lehman CD, Morris E, Pisano E, Schnall M, Sener S, Smith RA, Warner E, Yaffe M, Andrews KS, Russell CA; American Cancer Society Breast Cancer Advisory Group. American Cancer Society guidelines for breast screening with MRI as an adjunct to mammography. CA Cancer J Clin. 2007; 57:75-89.
Chen, J.H., et al., MRI evaluation of pathologically complete response and residual tumors in breast cancer after neoadjuvant chemotherapy. Cancer, 2008. 112(1): p. 17-26.
Sharma, U., et al., Longitudinal study of the assessment by MRI and diffusion-weighted imaging of tumor response in patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy. NMR Biomed, 2009. 22(1): p. 104-13.
Bando, H., et al., Imaging evaluation of pathological response in breast cancer after neoadjuvant chemotherapy by real-time sonoelastography and MRI. European Journal of Cancer-Supplement, 2008. 6(7): p. 66-66.
Bhattacharyya, M., et al., Using MRI to plan breast-conserving surgery following neoadjuvant chemotherapy for early breast cancer. Br J Cancer, 2008. 98(2): p. 289-93.
Partridge, S., Recurrence Rates After DCE-MRI Image Guided Planning for Breast-conserving Surgery Following Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer Patients. Breast Diseases: A Year Book Quarterly, 2008. 19(1): p. 91-91.
Tozaki, M., Diagnosis of breast cancer: MDCT versus MRI. Breast Cancer, 2008. 15(3): p. 205-211.
Partridge, S., et al., Accuracy of MR imaging for revealing residual breast cancer in patients who have undergone neoadjuvant chemotherapy. 2002, Am Roentgen Ray Soc. p. 1193-1199.
Berg WA, Blume JD, Cormack JB, Mendelson EB, Lehrer D, Böhm-Vélez M, Pisano ED, Jong RA, Evans WP, Morton MJ, Mahoney MC, Hovanessian Larsen L, Barr RG, Farria DM, Marques HS, Boparai K, for the ACRIN 6666 Investigators. Combined Screening With Ultrasound and Mammography vs Mammography Alone in Women at Elevated Risk of Breast Cancer. JAMA 2008;299(18):2151-2163.
Carson PL, Meyer CR, Scherzinger AL, Oughton TV. Breast imaging in coronal planes with simultaneous pulse echo and transmission ultrasound. Science 1981, Dec 4;214(4525):1141-3.
Andre MP, Janee HS, Martin PJ, Otto GP, Spivey BA, Palmer DA, "High-speed data acquisition in a diffraction tomography system employing large-scale toroidal arrays," International Journal of Imaging Systems and Technology 1997;Vol. 8, Issue 1:137-147.
Johnson SA, Borup DT, Wiskin JW, Natterer F, Wuebbling F, Zhang Y, Olsen C. Apparatus and Method for Imaging with Wavefields using Inverse Scattering Techniques. United States Patent 6,005,916 (1999).
Marmarelis VZ, Kim T, Shehada RE. Proceedings of the SPIE: Medical Imaging; Ultrasonic Imaging and Signal Processing 2003, Paper 5035-6.
Liu D-L, Waag RC. "Propagation and backpropagation for ultrasonic wavefront design," IEEE Trans. on Ultras. Ferro. and Freq. Contr. 1997;44(1):1-13.
Gemmeke, H and Ruiter, N. "3D ultrasound computer tomography for medical imaging". Nuclear instruments and methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol. 580, no. 2, pp 1057-1065, 2007.
Nicole V. Ruiter, Georg Göbel, Lutz Berger, Michael Zapf and Hartmut Gemmeke, "Realization of an optimized 3D USCT", Proc. SPIE 7968, 796805 (2011)
Duric N, Littrup P, Poulo L, Babkin A, Pevzner R, Holsapple E, Rama O, Glide C. Detection of Breast Cancer With Ultrasound Tomography: First Results with the Computerized Ultrasound Risk Evaluation (C.U.R.E) Prototype. Medical Physics Feb 2007; Vol 34 (2), pp. 773-785.
Glide CK, Duric N. Littrup P. A new method for quantitative analysis of mammographic density. Med Phys. 2007 Nov; Vol. 34, Issue 11:4491-4498.
Glide-Hurst C, Duric N, Littrup P. Volumetric breast density evaluation from ultrasound tomography images. Med Phys. 2008;Vol. 35, Issue 9, pp. 3988-3997.
Duric N, Li C, Littrup PJ, Huang L, Glide-Hurst C, Rama O, Bey-Knight L, Schmidt S, Xu Y, Lupinacci J. Detection and characterization of breast masses with ultrasound tomography: clinical results. Proc. SPIE 2008; 6920, 6920-28.
Li C, Duric N, Huang LJ. Clinical breast imaging using sound-speed reconstructions of ultrasound tomography data. Proc. SPIE 2008;6920, 6920-09.
Ranger B, Littrup P, Duric N, Chandiwala-Mody P, Li C, Schmidt S and Lupinacci J. Breast ultrasound tomography versus magnetic resonance imaging for clinical display of anatomy and tumor rendering: Preliminary results. AJR Am J Roentgenol Jan 2012; 198(1):233-9.
Lupinacci J, Duric N, Li C, Littrup P, Wang D, Rama O, Schmidt S. Monitoring of breast masses with ultrasound tomography for patients undergoing neoadjuvant chemotherapy. Proc. SPIE 2009;7265, 7265-43.
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