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Proceedings Article

Characterization of human breast cancer by scanning acoustic microscopy

[+] Author Affiliations
Di Chen, Eugene Malyarenko, Fedar Seviaryn, Ye Yuan, Christopher W. Greenway, Emil Strumban, Neb Duric, Roman Maev

Karmanos Cancer Institute (United States)

Mark Sherman, Gretchen Gierach

National Cancer Institute (United States)

Sudeshna Bandyopadhyay

Wayne State Univ. School of Medicine (United States)

Elena Maeva

Univ. of Windsor (Canada)

Proc. SPIE 8675, Medical Imaging 2013: Ultrasonic Imaging, Tomography, and Therapy, 86750M (March 29, 2013); doi:10.1117/12.2008660
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From Conference Volume 8675

  • Medical Imaging 2013: Ultrasonic Imaging, Tomography, and Therapy
  • Johan G. Bosch; Marvin M. Doyley
  • Lake Buena Vista (Orlando Area), Florida, USA | February 09, 2013

abstract

Objectives: The purpose of this study was to characterize human breast cancer tissues by the measurement of microacoustic properties. Methods: We investigated eight breast cancer patients using acoustic microscopy. For each patient, seven blocks of tumor tissue were collected from seven different positions around a tumor mass. Frozen sections (10 micrometer, μm) of human breast cancer tissues without staining and fixation were examined in a scanning acoustic microscope with focused transducers at 80 and 200 MHz. Hematoxylin and Eosin (H and E) stained sections from the same frozen breast cancer tissues were imaged by optical microscopy for comparison. Results: The results of acoustic imaging showed that acoustic attenuation and sound speed in cancer cell-rich tissue regions were significantly decreased compared with the surrounding tissue regions, where most components are normal cells/tissues, such as fibroblasts, connective tissue and lymphocytes. Our observation also showed that the ultrasonic properties were influenced by arrangements of cells and tissue patterns. Conclusions: Our data demonstrate that attenuation and sound speed imaging can provide biomechanical information of the tumor and normal tissues. The results also demonstrate the potential of acoustic microscopy as an auxiliary method for operative detection and localization of cancer affected regions. © (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Di Chen ; Eugene Malyarenko ; Fedar Seviaryn ; Ye Yuan ; Mark Sherman, et al.
" Characterization of human breast cancer by scanning acoustic microscopy ", Proc. SPIE 8675, Medical Imaging 2013: Ultrasonic Imaging, Tomography, and Therapy, 86750M (March 29, 2013); doi:10.1117/12.2008660; http://dx.doi.org/10.1117/12.2008660


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