Interstitial detection of gold nanoparticles in deep tissues with optical radiance using porcine phantom

Serge Grabtchak; Elena Tonkopi; William M. Whelan

doi:10.1117/12.2008962

29 March 2013 Interstitial detection of gold nanoparticles in deep tissues with optical radiance using porcine phantom

Serge Grabtchak, Elena Tonkopi, William M. Whelan

Proceedings Volume 8672, Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging; 86721E (2013) https://doi.org/10.1117/12.2008962
Event: SPIE Medical Imaging, 2013, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

We have applied an optical radiance technique to map localized inclusions of gold nanoparticles in a porcine phantom. Our goal was to show that combined spectroscopic and angular snapshots of phantoms allow the obtaining of information that is relevant for prostate cancer diagnostics. A combination of the radiance spectroscopy and white light spectroscopy was used to measure angular resolved light distribution in 600-900 nm spectral range inside the porcine phantom that mimics prostate geometry. Optical radiance defines a variation in the angular density of photons impinging on a selected point in the tissue from various directions. To obtain radiance data, a specially constructed optical probe with a well-defined angular detection window must be rotated along its axis. Characteristic spectro-angular snapshots of the phantom alone and with the localized inclusion of gold nanoparticles were obtained. The inclusions were formed by immersing a capillary filled with gold nanoparticles into selected locations in the phantom. For phantoms with gold inclusions, this approach allows the isolation of the spectroscopic signatures of the inclusions from the background and identification of inclusion locations in the angular domain. Detection of ~10¹⁰ gold nanoparticles (detector-inclusion separation 10 mm, source-detector separation 15 mm) in the porcine tissue was demonstrated. These encouraging results indicate a promising potential of radiance spectroscopy in early prostate cancer diagnostics with gold nanoparticles.

Citation Download Citation

Serge Grabtchak, Elena Tonkopi, and William M. Whelan "Interstitial detection of gold nanoparticles in deep tissues with optical radiance using porcine phantom", Proc. SPIE 8672, Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging, 86721E (29 March 2013); https://doi.org/10.1117/12.2008962

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
8 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Gold

Nanoparticles

Tissues

Plasmons

Spectroscopy

Tissue optics

Prostate

Show All Keywords

Keywords/Phrases

Search In:

Publication Years