Biomolecular hydrogel-based lipid bilayer array system

Joseph Najem; Alex Edgerton; Donald J. Leo

doi:10.1117/12.2010695

8 April 2013 Biomolecular hydrogel-based lipid bilayer array system

Joseph Najem, Alex Edgerton, Donald J. Leo

Proceedings Volume 8686, Bioinspiration, Biomimetics, and Bioreplication 2013; 86860C (2013) https://doi.org/10.1117/12.2010695
Event: SPIE Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring, 2013, San Diego, California, United States

Abstract

This work investigates the fabrication of hydrogel based lipid bilayers arrays using micro fabrication technologies that enable high precision in controlling the cell-scale droplets. Arrays of hydrogels that support curved aqueous lenses are deposited on two parallel substrates using lithography techniques on top of a network of Ag/AgCl electrodes. The first step in the fabrication process is to deposit silver electrodes using silver paint through a mask, a layer of silver chloride is then formed around the silver channels using another mask with the desired geometry. The hydrogel arrays are then achieved by exposing a thin film of photocrosslinkable hydrogel to UV light through a mask. Hydrogel arrays are fabricated using this technique, which is represents a relatively accurate and inexpensive method. The hydrogel structures can host a thin aqueous curved lenses containing phospholipids . Bilayer arrays can be formed by using a technique similar to the regulated attachment method, where mechanical force is used to bring adjacent aqueous lenses in contact.

Citation Download Citation

Joseph Najem, Alex Edgerton, and Donald J. Leo "Biomolecular hydrogel-based lipid bilayer array system", Proc. SPIE 8686, Bioinspiration, Biomimetics, and Bioreplication 2013, 86860C (8 April 2013); https://doi.org/10.1117/12.2010695

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