Development of a novel combined fluorescence and reflectance spectroscopy system for guiding high-grade glioma resections: confirmation of capability in lab experiments

Monirehalsadat Mousavi; Haiyan Xie; Zhiyuan Xie; Mikkel Brydegaard; Johan Axelsson; Stefan Andersson-Engels

doi:10.1117/12.2044480

18 November 2013 Development of a novel combined fluorescence and reflectance spectroscopy system for guiding high-grade glioma resections: confirmation of capability in lab experiments

Monirehalsadat Mousavi, Haiyan Xie, Zhiyuan Xie, Mikkel Brydegaard, Johan Axelsson, Stefan Andersson-Engels

Author Affiliations +

Proceedings Volume 9032, Biophotonics—Riga 2013; 90320M (2013) https://doi.org/10.1117/12.2044480
Event: 1st International Conference "Biophotonics Riga 2013", 2013, Riga, Latvia

Abstract

Total resection of glioblastoma multiform (GBM), the most common and aggressive malignant brain tumor, is challenging among other things due to difficulty in intraoperative discrimination between normal and residual tumor cells. This project demonstrates the potential of a system based on a combination of autofluorescence and diffuse reflectance spectroscopy to be useful as an intraoperative guiding tool. In this context, a system based on 5 LEDs coupled to optical fibers was employed to deliver UV/visible light to the sample sequentially. Remitted light from the tissue; including diffuse reflected and fluorescence of endogenous and exogenous fluorophores, as well as its photobleaching product, is transmitted to one photodiode and four avalanche photodiodes. This instrument has been evaluated with very promising results by performing various tissue-equivalent phantom laboratory and clinical studies on skin lesions.

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Monirehalsadat Mousavi, Haiyan Xie, Zhiyuan Xie, Mikkel Brydegaard, Johan Axelsson, and Stefan Andersson-Engels "Development of a novel combined fluorescence and reflectance spectroscopy system for guiding high-grade glioma resections: confirmation of capability in lab experiments", Proc. SPIE 9032, Biophotonics—Riga 2013, 90320M (18 November 2013); https://doi.org/10.1117/12.2044480

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