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Proceedings Article

Hand-held optoacoustic probe for three-dimensional imaging of human morphology and function

[+] Author Affiliations
X. Luís Deán-Ben, Daniel Razansky

Technical Univ. Munich (Germany)

Proc. SPIE 8943, Photons Plus Ultrasound: Imaging and Sensing 2014, 89430T (March 3, 2014); doi:10.1117/12.2040006
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From Conference Volume 8943

  • Photons Plus Ultrasound: Imaging and Sensing 2014
  • Alexander A. Oraevsky; Lihong V. Wang
  • San Francisco, California, United States | February 01, 2014

abstract

We report on a hand-held imaging probe for real-time optoacoustic visualization of deep tissues in three dimensions. The proposed solution incorporates a two-dimensional array of ultrasonic sensors densely distributed on a spherical surface, whereas illumination is performed coaxially through a cylindrical cavity in the array. Visualization of three-dimensional tomographic data at a frame rate of 10 images per second is enabled by parallel recording of 256 time-resolved signals for each individual laser pulse along with a highly efficient GPUbased real-time reconstruction. A liquid coupling medium (water), enclosed in a transparent membrane, is used to guarantee transmission of the optoacoustically generated waves to the ultrasonic detectors. Excitation at multiple wavelengths further allows imaging spectrally distinctive tissue chromophores such as oxygenated and deoxygenated haemoglobin. The performance is showcased by video-rate tracking of deep tissue vasculature and three-dimensional measurements of blood oxygenenation in a healthy human volunteer. The flexibility provided by the hand-held hardware design, combined with the real-time operation, makes the developed platform highly usable for both small animal research and clinical imaging in multiple indications, including cancer, inflammation, skin and cardiovascular diseases, diagnostics of lymphatic system and breast © (2014) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

X. Luís Deán-Ben and Daniel Razansky
" Hand-held optoacoustic probe for three-dimensional imaging of human morphology and function ", Proc. SPIE 8943, Photons Plus Ultrasound: Imaging and Sensing 2014, 89430T (March 3, 2014); doi:10.1117/12.2040006; http://dx.doi.org/10.1117/12.2040006


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