NIR-activated iron oxides as a new multi-functional contrast agent of photoacoustic imaging

Pei-Hsien Ting; Chih-Chia Huang; Meng-Lin Li

doi:10.1117/12.2037448

3 March 2014 NIR-activated iron oxides as a new multi-functional contrast agent of photoacoustic imaging

Pei-Hsien Ting, Chih-Chia Huang, Meng-Lin Li

Proceedings Volume 8943, Photons Plus Ultrasound: Imaging and Sensing 2014; 89434E (2014) https://doi.org/10.1117/12.2037448
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Iron oxide nanoparticles are commonly used contrast agents for theranostic nanomedicines because of their advantages of good biocompatibility, high stability in physiological conditions, low cytotoxicity and excellent safety record in clinical settings for human use. In this study, we developed a NIR-activated iron oxide (NIR-Fe₃O₄) nanoparticle as a new multi-functional contrast agent of photoacoustic (PA) imaging. Unlike traditional iron oxides, the developed NIR-Fe₃O₄ owns biocompatibility and optical tunability capable of providing strong optical absorption in the NIR range for PA signal generation. Its intrinsic magnetic property enables the active magnetic tumor targeting. Phantom experiments were performed to confirm the tunability of NIR-Fe₃O₄’s optical absorption in NIR and demonstrate its magnetic targeting capability. The PA signal response of NIR-Fe₃O₄ as a function of concentration was also investigated. The results showed that the PA signal of NIR-Fe₃O₄ with OD=1.25 was comparable to that of blood at 715 nm – the wavelength of peak absorption of the used NIR-Fe₃O₄. Moreover, the PA signal from NIR-Fe₃O₄ could be further improved by magnetic targeting. Overall, we proved that the potential of the developed NIR-Fe₃O₄ as a good tumor targeting contrast agent of PA imaging.

Citation Download Citation

Pei-Hsien Ting, Chih-Chia Huang, and Meng-Lin Li "NIR-activated iron oxides as a new multi-functional contrast agent of photoacoustic imaging", Proc. SPIE 8943, Photons Plus Ultrasound: Imaging and Sensing 2014, 89434E (3 March 2014); https://doi.org/10.1117/12.2037448

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