0

Full Content is available to subscribers

Subscribe/Learn More  >
Proceedings Article

Quantitative spectrally resolved intraoperative fluorescence imaging for neurosurgical guidance in brain tumor surgery: pre-clinical and clinical results

[+] Author Affiliations
Pablo A. Valdés, Valerie L. Jacobs, Frederic Leblond, Keith D. Paulsen, David W. Roberts

Dartmouth College (United States)

Brian C. Wilson

Univ. of Toronto (Canada)

Proc. SPIE 8928, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 892809 (March 20, 2014); doi:10.1117/12.2039090
Text Size: A A A
From Conference Volume 8928

  • Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics
  • Henry Hirschberg; Steen J. Madsen; E. Duco Jansen; Qingming Luo; Samarendra K. Mohanty; Nitish V. Thakor
  • San Francisco, California, United States | February 01, 2014

abstract

Fluorescence-guidance is a useful adjunct to maximize brain tumor resection but current commercial systems are limited by subjective assessment of fluorescence, low sensitivity and non-spectrally-resolved detection. We present a quantitative, spectrally-resolved system integrated onto a commercial neurosurgical microscope that performs spectrallyresolved detection and corrects for effects of tissue optical absorption and scattering on the detected fluorescence signal to image the true fluorophore concentration. Pre-clinical studies in rodent glioma models using multiple fluorophores (PpIX, fluorescein) and clinical studies demonstrate improved residual tumor tissue detection. This quantitative, spectrally-resolved technique opens the door to simultaneous image-guided surgery of multiple fluorophores in the visible and near infrared. © (2014) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Pablo A. Valdés ; Valerie L. Jacobs ; Frederic Leblond ; Brian C. Wilson ; Keith D. Paulsen, et al.
" Quantitative spectrally resolved intraoperative fluorescence imaging for neurosurgical guidance in brain tumor surgery: pre-clinical and clinical results ", Proc. SPIE 8928, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 892809 (March 20, 2014); doi:10.1117/12.2039090; http://dx.doi.org/10.1117/12.2039090


Access This Article
Sign In to Access Full Content
Please Wait... Processing your request... Please Wait.
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
 

Figures

Tables

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement


Buy this article ($18 for members, $25 for non-members).
Sign In