Full Content is available to subscribers

Subscribe/Learn More  >
Proceedings Article

X-ray fluorescence molecular imaging of high-Z tracers: investigation of a novel analyzer based setup

[+] Author Affiliations
Bernhard H. Müller, Thorsten R. C. Johnson

Ludwig-Maximilians-Univ. München (Germany)

Christoph Hoeschen

Helmholtz Zentrum München GmbH (Germany)

Florian Grüner

Univ. Hamburg (Germany)

Proc. SPIE 9033, Medical Imaging 2014: Physics of Medical Imaging, 90331J (March 19, 2014); doi:10.1117/12.2041948
Text Size: A A A
From Conference Volume 9033

  • Medical Imaging 2014: Physics of Medical Imaging
  • Bruce R. Whiting; Christoph Hoeschen
  • San Diego, California, USA | February 15, 2014

abstract

A novel x-ray fluorescence imaging setup for the in vivo detection of high-Z tracer distributions is investigated for its application in molecular imaging. The setup uses an energy resolved detection method based on a Bragg reflecting analyzer array together with a multiple scatter reducing radial collimator. The aim of this work is to investigate the potential application of this imaging method to in vivo imaging in humans. A proof of principle experiment modeling a partial setup for the detection of gold nano-particles was conducted in order to test the feasibility of the proposed imaging method. Furthermore a Monte Carlo simulation of the complete setup was created in order to quantify the dependence of the image quality on the applied radiation dose and on the geometrical collimator parameters as well as on the analyzer crystal parameters. The Monte Carlo simulation quantifies the signal-to-noise ratio per radiation dose and its dependence on the collimator parameters. Thereby the parameters needed for a dose efficient in vivo imaging of gold nano-particle based tracer distributions are quantified. However also a number of problems are found like the fluorescence emission as well as scatter from the collimator material obscuring the tracer fluorescence and the potentially large scan time. © (2014) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Bernhard H. Müller ; Christoph Hoeschen ; Florian Grüner and Thorsten R. C. Johnson
" X-ray fluorescence molecular imaging of high-Z tracers: investigation of a novel analyzer based setup ", Proc. SPIE 9033, Medical Imaging 2014: Physics of Medical Imaging, 90331J (March 19, 2014); doi:10.1117/12.2041948; http://dx.doi.org/10.1117/12.2041948


Access This Proceeding
Sign in or Create a personal account to Buy this proceeding ($15 for members, $18 for non-members).

Figures

Tables

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Proceeding
Sign in or Create a personal account to Buy this proceeding ($15 for members, $18 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.