Feasibility study of spectral computed tomography (CT) with gold as a new contrast agent

M. Müllner; H. Schlattl; U. Oeh; C. Hoeschen; O. Dietrich

doi:10.1117/12.2042988

19 March 2014 Feasibility study of spectral computed tomography (CT) with gold as a new contrast agent

M. Müllner, H. Schlattl, U. Oeh, C. Hoeschen, O. Dietrich

Proceedings Volume 9033, Medical Imaging 2014: Physics of Medical Imaging; 90334A (2014) https://doi.org/10.1117/12.2042988
Event: SPIE Medical Imaging, 2014, San Diego, California, United States

Abstract

Newly developed spectral CTs with a photon-counting and energy-selective detector provide the possibility to obtain additional information about an object’s absorption properties, the footprint of which can be found in the energy spectrum of the detected photons. These new CT systems are capable of yielding valuable insight into the elemental composition of the tissue and open up the way for new CT contrast agents by detecting element-specific K-edge patterns. Gold could be a promising new CT contrast agent. The major goal of this study is to determine the minimum amount of gold that is needed to use it as a spectral CT contrast agent for medical imaging in humans. To reach this goal, Monte Carlo simulations with EGSnrc were performed. The energy-selective detector, on which this study is based, has 6 energy bins and the energy thresholds can be selected freely. First different energy thresholds were analyzed to determine the best energy thresholds with respect to detecting gold. The K-edge imaging algorithm was then applied to the simulation results with these energy bins. The reconstructed images were evaluated with respect to signal-to-noise ratio, contrast-to-noise ratio and contrast. The K-edge imaging algorithm is able to convert the information in the six energy bins into three images, which correspond to the photoelectric effect, Compton scattering and gold content; however, it requires very long computing time. The simulations indicate that at least 0.2w% of gold are required to use it as a CT contrast agent in humans.

Citation Download Citation

M. Müllner, H. Schlattl, U. Oeh, C. Hoeschen, and O. Dietrich "Feasibility study of spectral computed tomography (CT) with gold as a new contrast agent", Proc. SPIE 9033, Medical Imaging 2014: Physics of Medical Imaging, 90334A (19 March 2014); https://doi.org/10.1117/12.2042988

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
8 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Gold

Monte Carlo methods

Sensors

Computed tomography

Signal to noise ratio

Compton scattering

Photons

Show All Keywords

Keywords/Phrases

Search In:

Publication Years