Celiac disease biodetection using lossy-mode resonances generated in tapered single-mode optical fibers

A. B. Socorro; J. M. Corres; I. Del Villar; I. R. Matias; F. J. Arregui

doi:10.1117/12.2059254

2 June 2014 Celiac disease biodetection using lossy-mode resonances generated in tapered single-mode optical fibers

A. B. Socorro, J. M. Corres, I. Del Villar, I. R. Matias, F. J. Arregui

Proceedings Volume 9157, 23rd International Conference on Optical Fibre Sensors; 91573J (2014) https://doi.org/10.1117/12.2059254
Event: OFS2014 23rd International Conference on Optical Fiber Sensors, 2014, Santander, Spain

Abstract

This work presents the development and test of an anti-gliadin antibodies biosensor based on lossy mode resonances (LMRs) to detect celiac disease. Several polyelectrolites were used to perform layer-by-layer assembly processes in order to generate the LMR and to fabricate a gliadin-embedded thin-film. The LMR shifted 20 nm when immersed in a 5 ppm anti-gliadin antibodies-PBS solution, what makes this bioprobe suitable for detecting celiac disease. This is the first time, to our knowledge, that LMRs are used to detect celiac disease and these results suppose promising prospects on the use of such phenomena as biological detectors.

Citation Download Citation

A. B. Socorro, J. M. Corres, I. Del Villar, I. R. Matias, and F. J. Arregui "Celiac disease biodetection using lossy-mode resonances generated in tapered single-mode optical fibers", Proc. SPIE 9157, 23rd International Conference on Optical Fibre Sensors, 91573J (2 June 2014); https://doi.org/10.1117/12.2059254

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