Design and synthesis of a fluorescent molecular imprinted polymer for use in an optical fibre-based cocaine sensor

Stephen P. Wren; Sergey A. Piletsky; Kal Karim; Paul Gascoine; Richard Lacey; Tong Sun; Kenneth T. V. Grattan

doi:10.1117/12.2059278

2 June 2014 Design and synthesis of a fluorescent molecular imprinted polymer for use in an optical fibre-based cocaine sensor

Stephen P. Wren, Sergey A. Piletsky, Kal Karim, Paul Gascoine, Richard Lacey, Tong Sun, Kenneth T. V. Grattan

Author Affiliations +

Proceedings Volume 9157, 23rd International Conference on Optical Fibre Sensors; 91574W (2014) https://doi.org/10.1117/12.2059278
Event: OFS2014 23rd International Conference on Optical Fiber Sensors, 2014, Santander, Spain

Abstract

Previously, we have developed chemical sensors using fibre optic-based techniques for the detection of Cocaine, utilising molecularly imprinted polymers (MIPs) containing fluorescein moieties as the signalling groups. Here, we report the computational design of a fluorophore which was incorporated into a MIP for the generation of a novel sensor that offers improved sensitivity for Cocaine with a detection range of 1-100μM. High selectivity for Cocaine over a suite of known Cocaine interferants (25μM) was also demonstrated by measuring changes in the intensity of fluorescence signals received from the sensor.

Citation Download Citation

Stephen P. Wren, Sergey A. Piletsky, Kal Karim, Paul Gascoine, Richard Lacey, Tong Sun, and Kenneth T. V. Grattan "Design and synthesis of a fluorescent molecular imprinted polymer for use in an optical fibre-based cocaine sensor", Proc. SPIE 9157, 23rd International Conference on Optical Fibre Sensors, 91574W (2 June 2014); https://doi.org/10.1117/12.2059278

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