Fabrication of a multiplexed microfluidic system for scaled up production of cross-linked biocatalytic microspheres

Mesuli B. Mbanjwa; Hao Chen; Louis Fourie; Sibusiso Ngwenya; Kevin Land

doi:10.1117/12.2065809

23 June 2014 Fabrication of a multiplexed microfluidic system for scaled up production of cross-linked biocatalytic microspheres

Mesuli B. Mbanjwa, Hao Chen, Louis Fourie, Sibusiso Ngwenya, Kevin Land

Author Affiliations +

Proceedings Volume 9257, Sensors, MEMS and Electro-Optical Systems; 92570M (2014) https://doi.org/10.1117/12.2065809
Event: Third Conference on Sensors, MEMS and Electro-Optic Systems, 2014, Skukuza, Kruger National Park, South Africa

Abstract

Multiplexed or parallelised droplet microfluidic systems allow for increased throughput in the production of emulsions and microparticles, while maintaining a small footprint and utilising minimal ancillary equipment. The current paper demonstrates the design and fabrication of a multiplexed microfluidic system for producing biocatalytic microspheres. The microfluidic system consists of an array of 10 parallel microfluidic circuits, for simultaneous operation to demonstrate increased production throughput. The flow distribution was achieved using a principle of reservoirs supplying individual microfluidic circuits. The microfluidic devices were fabricated in poly (dimethylsiloxane) (PDMS) using soft lithography techniques. The consistency of the flow distribution was determined by measuring the size variations of the microspheres produced. The coefficient of variation of the particles was determined to be 9%, an indication of consistent particle formation and good flow distribution between the 10 microfluidic circuits.

Citation Download Citation

Mesuli B. Mbanjwa, Hao Chen, Louis Fourie, Sibusiso Ngwenya, and Kevin Land "Fabrication of a multiplexed microfluidic system for scaled up production of cross-linked biocatalytic microspheres", Proc. SPIE 9257, Sensors, MEMS and Electro-Optical Systems, 92570M (23 June 2014); https://doi.org/10.1117/12.2065809

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