Observation and analysis on skin cancer induced by UVB irradiation using optical coherence tomography

Yunxia Wang; Shulian Wu; Hui Li; Xiaoxiao Zheng

doi:10.1117/12.2068551

17 September 2014 Observation and analysis on skin cancer induced by UVB irradiation using optical coherence tomography

Yunxia Wang, Shulian Wu, Hui Li, Xiaoxiao Zheng

Proceedings Volume 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014); 92301O (2014) https://doi.org/10.1117/12.2068551
Event: Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 2014, Wuhan, China

Abstract

Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the prevalent skin cancers, which have a quite high incidence in the white race. In recent years, however, their incidences have been increasing in the yellow race, resulting in a great threat to the public health. According to researches, chronics UVB irradiation (280nm~320nm) is the major culprit of skin cancer in humans. In our study, the model of UVB induced skin cancer was established firstly. Optical coherence tomography (OCT) combined with the histopathology was exploited to monitor the morphologic and histological changes of the process of UVB induced skin cancer. Meanwhile, this canceration process was systematically studied and analyzed from the perspective of tissue optics. The attenuation coefficient (μ_t) has a rising trend in the epidermis, but which shows a downward trend in the dermis. The results are conducive to understand the process of UVB-induced skin cancer and further be able to provide a reference for medical researchers.

Citation Download Citation

Yunxia Wang, Shulian Wu, Hui Li, and Xiaoxiao Zheng "Observation and analysis on skin cancer induced by UVB irradiation using optical coherence tomography", Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 92301O (17 September 2014); https://doi.org/10.1117/12.2068551

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