Multifunctional upconversion nanoprobe for tumor fluorescence imaging and near-infrared thermal therapy

Yanchun Wei; Qun Chen; Baoyan Wu; Da Xing

doi:10.1117/12.2069018

17 September 2014 Multifunctional upconversion nanoprobe for tumor fluorescence imaging and near-infrared thermal therapy

Yanchun Wei, Qun Chen, Baoyan Wu, Da Xing

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Proceedings Volume 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014); 923025 (2014) https://doi.org/10.1117/12.2069018
Event: Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 2014, Wuhan, China

Abstract

The combination of diagnostics and therapeutics is growing rapidly in cancer treatment. Here, using upconversion nanoparticles coated with chitosan conjugated with a targeting molecule and loaded with indocyanine green (ICG), an excitation-selectable nanoprobe with highly integrated functionalities, including the emission of visible and near-infrared (NIR) light, strong optical absorption in the NIR region and high photostability was developed. After injected in mice, the nanoprobes targeted to the tumor vascular system. NIR lasers (980 and 808 nm) were then selectively applied to the mice. The results show that, the emitted upconversion fluorescence and NIR fluorescence can be used in a complementary manner for high signal/noise ratio and sensitive tumor imaging for more precise tumor localization; Highly effective photothermal therapy can be realized using 808 nm laser irradiation. The upconversion fluorescence at 654 nm is useful for monitoring treatment effect during thermal therapy. In summary, using the nanoprobes, outstanding therapeutic efficacy could be realized and the nanofabrication strategy would highlight the promise of upconversion nanoparticles in cancer theranostics.

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Yanchun Wei, Qun Chen, Baoyan Wu, and Da Xing "Multifunctional upconversion nanoprobe for tumor fluorescence imaging and near-infrared thermal therapy", Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 923025 (17 September 2014); https://doi.org/10.1117/12.2069018

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KEYWORDS

Tumors

Luminescence

Nanoprobes

Absorption

Near infrared

Upconversion

Laser therapeutics

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