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Proceedings Article

Near infrared spectroscopy evaluation of bladder function: the impact of skin pigmentation on detection of physiologic change during voiding

[+] Author Affiliations
Babak Shadgan, Lynn Stothers

Ctr. for International Collaboration on Repair Discoveries (Canada)

Behnam Molavi, Andrew Macnab

The Univ. of British Columbia (Canada)

Sharif Mutabazi

Cure Medical Ctr. (Uganda)

Ronald Mukisa

Wallenberg Research Ctr. (South Africa)

Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93030U (February 26, 2015); doi:10.1117/12.2077824
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From Conference Volume 9303

  • Photonic Therapeutics and Diagnostics XI
  • Bernard Choi; Nikiforos Kollias; Haishan Zeng; Hyun Wook Kang; Brian J. F. Wong; Justus F. Ilgner; Alfred Nuttal; Claus-Peter Richter; Melissa C. Skala; Mark W. Dewhirst; Guillermo J. Tearney; Kenton W. Gregory; Laura Marcu; Andreas Mandelis; Michael D. Morris
  • San Francisco, California, United States | February 07, 2015

abstract

Background: Prior research indicates the epidermal pigment layer of human skin (Melanin) has a significant absorption coefficient in the near infra-red (NIR) region; hence attenuation of light in vivo is a potential confounder for NIR spectroscopy (NIRS). A NIRS method developed for transcutaneous evaluation of bladder function is being investigated as a means of improving the burden of bladder disease in sub-Saharan Africa. This required development of a simple wireless NIRS device suitable for use as a screening tool in patients with pigmented skin where the NIR light emitted would penetrate through the epidermal pigment layer and return in sufficient quantity to provide effective monitoring.

Methods: Two healthy subjects, one with pigmented skin and one with fair skin, were monitored as they voided spontaneously using the prototype transcutaneous NIRS device positioned over the bladder. The device was a self-contained wireless unit with light emitting diodes (wavelengths 760 and 850 nanometres) and interoptode distance of 4cm. The raw optical data were transmitted to a laptop where graphs of chromophore change were generated with proprietary software and compared between the subjects and with prior data from asymptomatic subjects.

Results: Serial monitoring was successful in both subjects. Voiding volumes varied between 350 and 380 cc. In each subject the patterns of chromophore change, trend and magnitude of change were similar and matched the physiologic increase in total and oxygenated hemoglobin recognized to occur in normal bladder contraction during voiding.

Conclusions: Skin pigmentation does not compromise the ability of transcutaneous NIRS to interrogate physiologic change in the bladder during bladder contraction in healthy subjects. © (2015) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Babak Shadgan ; Lynn Stothers ; Behnam Molavi ; Sharif Mutabazi ; Ronald Mukisa, et al.
" Near infrared spectroscopy evaluation of bladder function: the impact of skin pigmentation on detection of physiologic change during voiding ", Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93030U (February 26, 2015); doi:10.1117/12.2077824; http://dx.doi.org/10.1117/12.2077824


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