Real-time treatment light dose guidance of Pleural PDT: an update

Timothy C. Zhu; Michele M. Kim; Steven L. Jacques; Rozhin Penjweini; Andreea Dimofte; Jarod C. Finlay; Charles B. Simone M.D.; Keith A. Cengel; Joseph Friedberg

doi:10.1117/12.2080110

2 March 2015 Real-time treatment light dose guidance of Pleural PDT: an update

Timothy C. Zhu, Michele M. Kim, Steven L. Jacques, Rozhin Penjweini, Andreea Dimofte, Jarod C. Finlay, Charles B. Simone M.D., Keith A. Cengel, Joseph Friedberg

Author Affiliations +

Proceedings Volume 9308, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV; 930809 (2015) https://doi.org/10.1117/12.2080110
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

The goal of this study was to develop and improve an infrared (IR) navigation system to deliver light dose uniformly during intracavitory PDT by tracking the movement of the light source and providing real-time feedback on the light fluence rate on the entire cavity surface area. In the current intrapleural PDT protocol, several detectors placed in selected locations in the pleural cavity monitor the light doses. To improve the delivery of light dose uniformity, an IR camera system is used to track the motion of the light source as well as the surface contour of the pleural cavity. Monte- Carlo simulation is used to improve the calculation algorithm for the effect of light that undergoes multiple scattering along the surface in addition to an improvement of the direct light calculation using an improved model that accounts for the anisotropy of the light from the light source.

Citation Download Citation

Timothy C. Zhu, Michele M. Kim, Steven L. Jacques, Rozhin Penjweini, Andreea Dimofte, Jarod C. Finlay, Charles B. Simone M.D., Keith A. Cengel, and Joseph Friedberg "Real-time treatment light dose guidance of Pleural PDT: an update", Proc. SPIE 9308, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV, 930809 (2 March 2015); https://doi.org/10.1117/12.2080110

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