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In recent year, for the treatment of gastric cancer the laparoscopic surgery is performed, which has good benefits, such
as low-burden, low-invasive and the efficacy is equivalent to the open surgery. For identify location of the tumor
intraperitoneally for extirpation of the gastric cancer, several points of charcoal ink is injected around the primary tumor.
However, in the time of laparoscopic operation, it is difficult to estimate specific site of primary tumor, because the
injected charcoal ink diffusely spread to the area distant from the tumor in the stomach. Therefore, a broad area should
be resected which results in a great stress for the patients. To overcome this problem, we focused in the near-infrared
wavelength of 1000nm band which have high biological transmission. In this study, we developed a fluorescent clip
which was realized with glass phosphor (Yb3+, Nd3+ doped to Bi2O3-B2O3 based glasses. λp: 976 nm, FWHM: 100 nm,
size: 2x1x3 mm) and the laparoscopic fluorescent detection system for clip-derived near-infrared light. To evaluate
clinical performance of a fluorescent clip and the laparoscopic fluorescent detection system, we used resected stomach
(thickness: 13 mm) from the patients. Fluorescent clip was fixed on the gastric mucosa, and an excitation light (λ: 808
nm) was irradiated from outside of stomach for detection of fluorescence through stomach wall. As a result, fluorescence
emission from the clip was successfully detected. Furthermore, we confirmed that detection sensitivity of the emission of
fluorescence from the clip depends on the output power of the excitation light. We conformed that the fluorescent clip in
combination with laparoscopic fluorescent detection system is very useful method to identify the exact location of the
primary gastric cancer.
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