A novel broadband Raman endoscopy for in vivo diagnosis of intestinal metaplasia in the stomach

Kan Lin; Mads Sylvest Bergholt; Jianfeng Wang; Wei Zheng; Hongzhi Xu; Jian-lin Ren; Khek Yu Ho; Ming Teh; Khay Guan Yeoh; Zhiwei Huang

doi:10.1117/12.2080896

4 March 2015 A novel broadband Raman endoscopy for in vivo diagnosis of intestinal metaplasia in the stomach

Kan Lin, Mads Sylvest Bergholt, Jianfeng Wang, Wei Zheng, Hongzhi Xu, Jian-lin Ren, Khek Yu Ho, Ming Teh, Khay Guan Yeoh, Zhiwei Huang

Author Affiliations +

Proceedings Volume 9313, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII; 93130I (2015) https://doi.org/10.1117/12.2080896
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

We report a novel simultaneous fingerprint (FP) and high-wavenumber (HW) fiber-optic Raman spectroscopy developed for in vivo diagnosis of intestinal metaplasia (IM) in the stomach under wide-field endoscopic imaging. The FP/HW Raman endoscopy technique was performed to differentiate IM from normal tissues with sensitivity of 89% and specificity of 83%. This study shows the great potential of the FP/HW Raman endoscopic technique for early diagnosis of non-neoplastic gastric disease in vivo during routine endoscopic examination.

Citation Download Citation

Kan Lin, Mads Sylvest Bergholt, Jianfeng Wang, Wei Zheng, Hongzhi Xu, Jian-lin Ren, Khek Yu Ho, Ming Teh, Khay Guan Yeoh, and Zhiwei Huang "A novel broadband Raman endoscopy for in vivo diagnosis of intestinal metaplasia in the stomach", Proc. SPIE 9313, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII, 93130I (4 March 2015); https://doi.org/10.1117/12.2080896

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