Non-invasive submilligram level quantification of in vivo blood components with slitless high-sensitivity spectrometer and noncooled NIR detector

Ryosuke Kuribayashi; Hiromitsu Furukawa

doi:10.1117/12.2078769

4 March 2015 Non-invasive submilligram level quantification of in vivo blood components with slitless high-sensitivity spectrometer and noncooled NIR detector

Ryosuke Kuribayashi, Hiromitsu Furukawa

Author Affiliations +

Proceedings Volume 9313, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII; 931314 (2015) https://doi.org/10.1117/12.2078769
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

By using a “slit-less” Fourier-transform spectrometer, we demonstrate that cardiac-pulsation amplitude of absorbance can be extracted from 3.5-level absorbance unit (AU) spectra of a human fingertip with a resolution of < 0.0005 AU and a spectral resolution of < several tens of nanometers, even with a low-cost “non-cooled” NIR detector. From the extracted spectrum over 1,000-1,400 nm, the average amounts of pulsating blood components (water, HbO₂, and lipids/proteins) in a fingertip are deduced in the sub-milligram order. The results indicate the capacity of the spectrometer for a portable non-invasive blood monitor as well as for a high-end analytic instrument.

Citation Download Citation

Ryosuke Kuribayashi and Hiromitsu Furukawa "Non-invasive submilligram level quantification of in vivo blood components with slitless high-sensitivity spectrometer and noncooled NIR detector", Proc. SPIE 9313, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII, 931314 (4 March 2015); https://doi.org/10.1117/12.2078769

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