Quantitative assessment of corneal biomechanical properties using optical coherence elastography and a modified Rayleigh Lamb-frequency model

Zhaolong Han; Salavat R. Aglyamov; Jiasong Li; Manmohan Singh; Shang Wang; Srilatha Vantipalli; Chen Wu; Chih-hao Liu; Michael D. Twa; Kirill V. Larin

doi:10.1117/12.2079542

20 March 2015 Quantitative assessment of corneal biomechanical properties using optical coherence elastography and a modified Rayleigh Lamb-frequency model

Zhaolong Han, Salavat R. Aglyamov, Jiasong Li, Manmohan Singh, Shang Wang, Srilatha Vantipalli, Chen Wu, Chih-hao Liu, Michael D. Twa, Kirill V. Larin

Author Affiliations +

Proceedings Volume 9307, Ophthalmic Technologies XXV; 930719 (2015) https://doi.org/10.1117/12.2079542
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

This study reports the application of a modified Rayleigh-Lamb frequency equation (RLFE) to a noncontact optical coherence elastography (OCE) method for quantitative assessment of the biomechanical properties of a porcine cornea. A focused air-pulse induced an elastic wave in the cornea, which was imaged by a phasestabilized optical coherence tomography (OCT) system. From the displacement data acquired by the OCT system, phase velocities of the mechanical wave were extracted by spectral analysis using a fast Fourier transform. Experiments were conducted on 2% agar phantom samples, and the Young’s moduli were assessed by the Rayleigh-Lamb frequency equation, which was validated using uniaxial mechanical compression testing. The Rayleigh-Lamb frequency equation was then applied to OCE data from a normal porcine cornea, in which the fluid-solid effect was considered. The Young’s modulus of the porcine cornea was measured to be ~60 kPa and the shear viscosity was ~0.33 Pa·s. The combination of OCE and RLFE is a promising noninvasive method for the estimation of the biomechanical properties of the cornea in vivo.

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Zhaolong Han, Salavat R. Aglyamov, Jiasong Li, Manmohan Singh, Shang Wang, Srilatha Vantipalli, Chen Wu, Chih-hao Liu, Michael D. Twa, and Kirill V. Larin "Quantitative assessment of corneal biomechanical properties using optical coherence elastography and a modified Rayleigh Lamb-frequency model", Proc. SPIE 9307, Ophthalmic Technologies XXV, 930719 (20 March 2015); https://doi.org/10.1117/12.2079542

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