Dynamic image reconstruction in time-resolved diffuse optical tomography

Samuel Powell; Robert J. Cooper; Jeremy C. Hebden; Simon R. Arridge

doi:10.1117/12.2077465

5 March 2015 Dynamic image reconstruction in time-resolved diffuse optical tomography

Samuel Powell, Robert J. Cooper, Jeremy C. Hebden, Simon R. Arridge

Proceedings Volume 9319, Optical Tomography and Spectroscopy of Tissue XI; 93191I (2015) https://doi.org/10.1117/12.2077465
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Optical imaging techniques provide a means of monitoring haemodynamics and tissue oxygenation by virtue of the differing absorption spectra of relevant endogenous chromophores. Whilst time-domain diffuse optical tomography offers sufficient sensitivity to produce full three dimensional images of such properties through the entire infant brain, standard approaches to the imaging protocol and reconstruction methods limit the temporal resolution which can be achieved without an unacceptable degradation in the image quality. In this work we employ spatio-temporal regularisation by means of a variational form Kalman filter to achieve significantly improved temporal resolution whilst maintaining image quality. We demonstrate this approach in a dynamic phantom study where we successfully track moving absorbing and scattering targets using the MONSTIR II instrument developed at University College London.

Citation Download Citation

Samuel Powell, Robert J. Cooper, Jeremy C. Hebden, and Simon R. Arridge "Dynamic image reconstruction in time-resolved diffuse optical tomography", Proc. SPIE 9319, Optical Tomography and Spectroscopy of Tissue XI, 93191I (5 March 2015); https://doi.org/10.1117/12.2077465

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