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Proceedings Article

Anti-tumor response induced by immunologically modified carbon nanotubes and laser irradiation using rat mammary tumor model

[+] Author Affiliations
Joseph T. Acquaviva, Aamr M. Hasanjee, Cody F. Bahavar, Fefian Zhou, Wei R. Chen

Univ. of Central Oklahoma (United States)

Hong Liu

Univ. of Oklahoma (United States)

Eric W. Howard, Liz C. Bullen

The Univ. of Oklahoma Health Sciences Ctr. (United States)

Ricardo P. Silvy

Southwest NanoTechnologies Inc. (United States)

Proc. SPIE 9324, Biophotonics and Immune Responses X, 932415 (March 9, 2015); doi:10.1117/12.2080890
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From Conference Volume 9324

  • Biophotonics and Immune Responses X
  • Wei R. Chen
  • San Francisco, California, United States | February 07, 2015

abstract

Laser immunotherapy (LIT) is being developed as a treatment modality for metastatic cancer which can destroy primary tumors and induce effective systemic anti-tumor responses by using a targeted treatment approach in conjunction with the use of a novel immunoadjuvant, glycated chitosan (GC). In this study, Non-invasive Laser Immunotherapy (NLIT) was used as the primary treatment mode. We incorporated single-walled carbon nanotubes (SWNTs) into the treatment regimen to boost the tumor-killing effect of LIT. SWNTs and GC were conjugated to create a completely novel, immunologically modified carbon nanotube (SWNT-GC). To determine the efficacy of different laser irradiation durations, 5 minutes or 10 minutes, a series of experiments were performed. Rats were inoculated with DMBA-4 cancer cells, a highly aggressive metastatic cancer cell line. Half of the treatment group of rats receiving laser irradiation for 10 minutes survived without primary or metastatic tumors. The treatment group of rats receiving laser irradiation for 5 minutes had no survivors. Thus, Laser+SWNT-GC treatment with 10 minutes of laser irradiation proved to be effective at reducing tumor size and inducing long-term anti-tumor immunity. © (2015) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Joseph T. Acquaviva ; Aamr M. Hasanjee ; Cody F. Bahavar ; Fefian Zhou ; Hong Liu, et al.
" Anti-tumor response induced by immunologically modified carbon nanotubes and laser irradiation using rat mammary tumor model ", Proc. SPIE 9324, Biophotonics and Immune Responses X, 932415 (March 9, 2015); doi:10.1117/12.2080890; http://dx.doi.org/10.1117/12.2080890


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