First-harmonic sensitivity functions for a linearised diffusion model of ultrasound-modulated optical tomography

Samuel Powell; Simon R. Arridge; Terence S. Leung

doi:10.1117/12.2077435

11 March 2015 First-harmonic sensitivity functions for a linearised diffusion model of ultrasound-modulated optical tomography

Samuel Powell, Simon R. Arridge, Terence S. Leung

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Proceedings Volume 9323, Photons Plus Ultrasound: Imaging and Sensing 2015; 932342 (2015) https://doi.org/10.1117/12.2077435
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Ultrasound-modulated optical tomography is an emerging biomedical imaging modality which uses the spatially localised acoustically-driven modulation of coherent light as a probe of the structure and optical properties of biological tissues. In this work we model the first-harmonic flux generated by the coupled physics using a simple linearised diffusion-style forward model. We derive analytical expressions for the sensitivity of this measurement type with respect to the optical absorption and scattering coefficients. These correlation measurement density functions can be employed as part of an image-reconstruction procedure capable of reconstructing quantitative images of the optical properties of a medium under investigation.

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Samuel Powell, Simon R. Arridge, and Terence S. Leung "First-harmonic sensitivity functions for a linearised diffusion model of ultrasound-modulated optical tomography", Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 932342 (11 March 2015); https://doi.org/10.1117/12.2077435

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KEYWORDS

Ultrasound-modulated optical tomography

Modulation

Acoustics

Acousto-optics

Sensors

Ultrasonography

Absorption

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