Detecting inflammation and fibrosis in bowel wall with photoacoustic imaging in a Crohn's disease animal model

Guan Xu; Laura A. Johnson; Jack Hu; Jonathan R. Dillman; Peter D. R. Higgins; Xueding Wang

doi:10.1117/12.2077634

11 March 2015 Detecting inflammation and fibrosis in bowel wall with photoacoustic imaging in a Crohn's disease animal model

Guan Xu, Laura A. Johnson, Jack Hu, Jonathan R. Dillman, Peter D. R. Higgins, Xueding Wang

Author Affiliations +

Proceedings Volume 9323, Photons Plus Ultrasound: Imaging and Sensing 2015; 932347 (2015) https://doi.org/10.1117/12.2077634
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Crohn’s disease (CD) is an autoimmune disease affecting 700,000 people in the United States. This condition may cause obstructing intestinal narrowings (strictures) due to inflammation, fibrosis (deposition of collagen), or a combination of both. Utilizing the unique strong optical absorption of hemoglobin at 532 nm and collagen at 1370 nm, this study investigated the feasibility of non-invasively characterizing intestinal strictures using photoacoustic imaging (PAI). Three normal controls, ten pure inflammation and 9 inflammation plus fibrosis rat bowel wall samples were imaged. Statistical analysis of the PA measurements has shown the capability of discriminating the purely inflammatory from mixed inflammatory and fibrotic strictures.

Citation Download Citation

Guan Xu, Laura A. Johnson, Jack Hu, Jonathan R. Dillman, Peter D. R. Higgins, and Xueding Wang "Detecting inflammation and fibrosis in bowel wall with photoacoustic imaging in a Crohn's disease animal model", Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 932347 (11 March 2015); https://doi.org/10.1117/12.2077634

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