Performance evaluation for different sensing surface of BICELLs bio-transducers for dry eye biomarkers

M. F. Laguna; M. Holgado; B. Santamaría; A. López; M. Maigler; A. Lavín; J. de Vicente; J. Soria; T. Suarez; C. Bardina; M. Jara; F. J. Sanza; R. Casquel; A. Otón; T. Riesgo

doi:10.1117/12.2077174

11 March 2015 Performance evaluation for different sensing surface of BICELLs bio-transducers for dry eye biomarkers

M. F. Laguna, M. Holgado, B. Santamaría, A. López, M. Maigler, A. Lavín, J. de Vicente, J. Soria, T. Suarez, C. Bardina, M. Jara, F. J. Sanza, R. Casquel, A. Otón, T. Riesgo

Author Affiliations +

Proceedings Volume 9337, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XII; 93370J (2015) https://doi.org/10.1117/12.2077174
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Biophotonic Sensing Cells (BICELLs) are demonstrated to be an efficient technology for label-free biosensing and in concrete for evaluating dry eye diseases. The main advantage of BICELLs is its capability to be used by dropping directly a tear into the sensing surface without the need of complex microfluidics systems. Among this advantage, compact Point of Care read-out device is employed with the capability of evaluating different types of BICELLs packaged on Biochip-Kits that can be fabricated by using different sensing surfaces material. In this paper, we evaluate the performance of the combination of three sensing surface materials: (3-Glycidyloxypropyl) trimethoxysilane (GPTMS), SU-8 resist and Nitrocellulose (NC) for two different biomarkers relevant for dry eye diseases: PRDX-5 and ANXA-11.

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M. F. Laguna, M. Holgado, B. Santamaría, A. López, M. Maigler, A. Lavín, J. de Vicente, J. Soria, T. Suarez, C. Bardina, M. Jara, F. J. Sanza, R. Casquel, A. Otón, and T. Riesgo "Performance evaluation for different sensing surface of BICELLs bio-transducers for dry eye biomarkers", Proc. SPIE 9337, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XII, 93370J (11 March 2015); https://doi.org/10.1117/12.2077174

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