Microscopic x-ray luminescence computed tomography

Wei Zhang; Dianwen Zhu; Kun Zhang; Changqing Li

doi:10.1117/12.2076797

12 March 2015 Microscopic x-ray luminescence computed tomography

Wei Zhang, Dianwen Zhu, Kun Zhang, Changqing Li

Proceedings Volume 9316, Multimodal Biomedical Imaging X; 93160M (2015) https://doi.org/10.1117/12.2076797
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

X-ray luminescence computed tomography (XLCT) was emerged as a new hybrid imaging modality, in which the x-rays are used to excite phosphors emitting optical photons to be measured for imaging. In this paper, we reported a microscopic x-ray luminescence computed tomography (microXLCT) with a spatial resolution up to hundreds of micrometers for deep targets. We use a superfine x-ray pencil beam to scan the phosphor targets. The superfine x-ray pencil beam is generated by a small collimator mounted in front of a powerful x-ray tube (93212, Oxford Instrument). A CT detector is used to image the x-ray beam. We have generated an x-ray beam with a diameter of 192 micrometers with a collimator of 100 micrometers in diameter. The emitted optical photons on the top surface of phantom are reflected by a mirror and acquired by an electron multiplier charge-coupled device (EMCCD) camera (C9100-13, Hamamatsu Photonics). The microXLCT imaging system is built inside an x-ray shielding and light tight cabinet. The EMCCD camera is placed in a lead box. All the imaging components are controlled by a VC++ program. The optical photon propagation is modeled with the diffusion equation solved by the finite element method. We have applied different regularization methods including L² and L¹ in the microXLCT reconstruction algorithms. Numerical simulations and phantom experiments are used to validate the microXLCT imaging system.

Citation Download Citation

Wei Zhang, Dianwen Zhu, Kun Zhang, and Changqing Li "Microscopic x-ray luminescence computed tomography", Proc. SPIE 9316, Multimodal Biomedical Imaging X, 93160M (12 March 2015); https://doi.org/10.1117/12.2076797

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