Boundary conditions independent diffuse correlation spectroscopy

Mamadou Diop; Keith St. Lawrence

doi:10.1117/12.2077799

12 March 2015 Boundary conditions independent diffuse correlation spectroscopy

Mamadou Diop, Keith St. Lawrence

Proceedings Volume 9319, Optical Tomography and Spectroscopy of Tissue XI; 931917 (2015) https://doi.org/10.1117/12.2077799
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Diffuse correlation spectroscopy (DCS) can measure perfusion changes in deep tissue. However, DCS requires solving the diffusion equation with the proper boundary conditions which can be very difficult and even impossible in many cases. We present a DCS approach that is independent of boundary conditions. The approach is based on measuring the probability distribution function (PDF) of the photons’ pathlengths by deconvolving the temporal point-spread function and the instrument-response function obtained from time-resolved measurements. The recovered PDF was then used to fit the field correlation function to extract perfusion changes. This approach can be applied to any geometry and is valid for diffusive, single-scattering and multiple-scattering, but non-diffusive media.

Citation Download Citation

Mamadou Diop and Keith St. Lawrence "Boundary conditions independent diffuse correlation spectroscopy", Proc. SPIE 9319, Optical Tomography and Spectroscopy of Tissue XI, 931917 (12 March 2015); https://doi.org/10.1117/12.2077799

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available