Silica-coated gold nanostars for surface-enhanced resonance Raman spectroscopy mapping of integrins in breast cancer cells

Michael B. Fenn Jr.; Nikša Roki; Chris Bashur

doi:10.1117/12.2080443

20 March 2015 Silica-coated gold nanostars for surface-enhanced resonance Raman spectroscopy mapping of integrins in breast cancer cells

Michael B. Fenn Jr., Nikša Roki, Chris Bashur

Author Affiliations +

Proceedings Volume 9340, Plasmonics in Biology and Medicine XII; 934006 (2015) https://doi.org/10.1117/12.2080443
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Surface-Enhanced Resonance Raman Spectroscopy (SERRS) has great potential for improving cancer research and diagnosis. Capable of sub-femtomolar detection, and a high degree of multiplexing, SERRS is an attractive new technique for studying cancer biology. We have developed PEGylated silica-coated gold nanostars that can be tuned to match the Raman laser-light source wavelength, providing high-level SERRS/SERS enhancement when combined with various reporter molecules. Furthermore, the particles were conjugated with cyclo-RGDf/k peptide to investigate integrin expression of breast cancer cells using high-speed Raman mapping. We propose that this may provide a better understanding of the role of integrins in breast cancer invasiveness.

Citation Download Citation

Michael B. Fenn Jr., Nikša Roki, and Chris Bashur "Silica-coated gold nanostars for surface-enhanced resonance Raman spectroscopy mapping of integrins in breast cancer cells", Proc. SPIE 9340, Plasmonics in Biology and Medicine XII, 934006 (20 March 2015); https://doi.org/10.1117/12.2080443

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