Quantifying the optical properties of turbid media using polarization sensitive hyperspectral imaging (SkinSpect): two-layer optical phantom studies

Fartash Vasefi; Nicholas MacKinnon; Rolf Saager; Anthony J. Durkin; Robert Chave; Daniel L. Farkas

doi:10.1117/12.2186031

25 March 2015 Quantifying the optical properties of turbid media using polarization sensitive hyperspectral imaging (SkinSpect): two-layer optical phantom studies

Fartash Vasefi, Nicholas MacKinnon, Rolf Saager, Anthony J. Durkin, Robert Chave, Daniel L. Farkas

Author Affiliations +

Proceedings Volume 9328, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XIII; 93280A (2015) https://doi.org/10.1117/12.2186031
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

A polarization-sensitive hyperspectral imaging system (SkinSpect) has been built and evaluated using two-layer tissue phantoms, fabricated to mimic the optical properties of melanin in different epidermal thickness and hemoglobin in dermal layers. Multiple tissue-mimicking phantoms with varying top layer thicknesses were measured for optical system calibration and performance testing. Phantom properties were characterized and validated using SkinSpect. The resulting analysis shows that the proposed system is capable of distinguishing and differentiating the layer-dependent absorption spectra and the depths at which this absorption occurs.

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Fartash Vasefi, Nicholas MacKinnon, Rolf Saager, Anthony J. Durkin, Robert Chave, and Daniel L. Farkas "Quantifying the optical properties of turbid media using polarization sensitive hyperspectral imaging (SkinSpect): two-layer optical phantom studies", Proc. SPIE 9328, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XIII, 93280A (25 March 2015); https://doi.org/10.1117/12.2186031

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