Proceedings Article

Bridging molecular and cellular biology with optics (Presentation Video)

[+] Author Affiliations
Gabriel Popescu

Univ. of Illinois at Urbana-Champaign (United States)

Proc. SPIE 9339, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VII, 933902 (April 27, 2015); doi:10.1117/12.2179067
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From Conference Volume 9339

  • Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VII
  • Samuel Achilefu; Ramesh Raghavachari
  • San Francisco, California, United States | February 07, 2015

abstract

Understanding the structure and function of living cells from the nano to the micron scale remains a grand challenge. While X-ray diffraction and electron microscopy reveal nanoscale information from cellular structures, they operate with lifeless specimens. By contrast, optical techniques are well suitable for studying live cells. However, the resolution of the far-field “linear” microscopy is approximately 300 nm, a manifestation of Heisenberg’s uncertainty relation. Thus, pushing the biophotonics investigation toward the molecular scale is faced with significant challenges but also with unique opportunities. We will describe various principles dedicated to this goal and present some recent advances in phase sensitive measurements. © (2015) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
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Citation

Gabriel Popescu
" Bridging molecular and cellular biology with optics (Presentation Video) ", Proc. SPIE 9339, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VII, 933902 (April 27, 2015); doi:10.1117/12.2179067; http://dx.doi.org/10.1117/12.2179067


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