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Proceedings Article

Sensing, capturing, and interrogation of single virus particles with solid state nanopores

[+] Author Affiliations
Armin Darvish, Gaurav Goyal, Minjun Kim

Drexel Univ. (United States)

Proc. SPIE 9490, Advances in Global Health through Sensing Technologies 2015, 94900M (May 13, 2015); doi:10.1117/12.2183320
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From Conference Volume 9490

  • Advances in Global Health through Sensing Technologies 2015
  • Šárka O. Southern
  • Baltimore, Maryland, United States | April 20, 2015

abstract

Solid-state nanopores have gained much attention as a bioanalytical platform. By virtue of their tunable nanoscale dimensions, nanopore sensors can a spatial resolution that spans a wide range of biological species from a single-molecule to a single virus or microorganism. Several groups have already used solid-state nanopores for tag-free detection of viruses. However, no one has reported use of nanopores to capture a single virus for further interrogation by the electric field inside nanopores. In this paper we will report detection of single HIV-1 particle with solid-state nanopores and demonstrate the ability to trap a single HIV-1 particle on top of a nanopore and force it to squeeze through the pore using an electric field. © (2015) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Armin Darvish ; Gaurav Goyal and Minjun Kim
" Sensing, capturing, and interrogation of single virus particles with solid state nanopores ", Proc. SPIE 9490, Advances in Global Health through Sensing Technologies 2015, 94900M (May 13, 2015); doi:10.1117/12.2183320; http://dx.doi.org/10.1117/12.2183320


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