Solid-state nanopores have gained much attention as a bioanalytical platform. By virtue of their tunable nanoscale dimensions, nanopore sensors can a spatial resolution that spans a wide range of biological species from a single-molecule to a single virus or microorganism. Several groups have already used solid-state nanopores for tag-free detection of viruses. However, no one has reported use of nanopores to capture a single virus for further interrogation by the electric field inside nanopores. In this paper we will report detection of single HIV-1 particle with solid-state nanopores and demonstrate the ability to trap a single HIV-1 particle on top of a nanopore and force it to squeeze through the pore using an electric field.
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Armin Darvish ; Gaurav Goyal and Minjun Kim
Sensing, capturing, and interrogation of single virus particles with solid state nanopores
", Proc. SPIE 9490, Advances in Global Health through Sensing Technologies 2015, 94900M (May 13, 2015); doi:10.1117/12.2183320; http://dx.doi.org/10.1117/12.2183320