Nature-inspired magnetoelastic biosentinels for the detection of pathogenic bacteria in stagnant liquids

Shin Horikawa; Yating Chai; Howard C. Wikle III; Jing Dai; Jiajia Hu; Sang-Jin Suh; Vitaly Vodyanoy; Bryan A. Chin

doi:10.1117/12.2087766

13 May 2015 Nature-inspired magnetoelastic biosentinels for the detection of pathogenic bacteria in stagnant liquids

Shin Horikawa, Yating Chai, Howard C. Wikle III, Jing Dai, Jiajia Hu, Sang-Jin Suh, Vitaly Vodyanoy, Bryan A. Chin

Proceedings Volume 9488, Sensing for Agriculture and Food Quality and Safety VII; 94880C (2015) https://doi.org/10.1117/12.2087766
Event: SPIE Sensing Technology + Applications, 2015, Baltimore, MD, United States

Abstract

This paper presents an investigation into magnetoelastic (ME) biosentinels that capture and detect low-concentration pathogenic bacteria in stagnant liquids. The ME biosentinels are designed to mimic a variety of white blood cell types, known as the main defensive mechanism in the human body against different pathogenic invaders. The ME biosentinels are composed of a freestanding ME resonator coated with an engineered phage that specifically binds with the pathogens of interest. These biosentinels are ferromagnetic and thus can be moved through a liquid by externally applied magnetic fields. In addition, when a time-varying magnetic field is applied, the ME biosentinels can be placed into mechanical resonance by magnetostriction. As soon as the biosentinels bind with the target pathogen through the phage-based biomolecular recognition, a change in the biosentinel’s resonant frequency occurs, and thereby the presence of the target pathogen can be detected. Detection of Bacillus anthracis spores under stagnant flow conditions was demonstrated.

Citation Download Citation

Shin Horikawa, Yating Chai, Howard C. Wikle III, Jing Dai, Jiajia Hu, Sang-Jin Suh, Vitaly Vodyanoy, and Bryan A. Chin "Nature-inspired magnetoelastic biosentinels for the detection of pathogenic bacteria in stagnant liquids", Proc. SPIE 9488, Sensing for Agriculture and Food Quality and Safety VII, 94880C (13 May 2015); https://doi.org/10.1117/12.2087766

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available