Erythrocyte-derived optical nano-vesicles as theranostic agents

Jenny T. Mac; Vicente Nunez; Baharak Bahmani; Yadir Guerrero; Jack Tang; Valentine I. Vullev; Bahman Anvari

doi:10.1117/12.2183587

13 July 2015 Erythrocyte-derived optical nano-vesicles as theranostic agents

Jenny T. Mac, Vicente Nunez, Baharak Bahmani, Yadir Guerrero, Jack Tang, Valentine I. Vullev, Bahman Anvari

Proceedings Volume 9540, Novel Biophotonics Techniques and Applications III; 95400H (2015) https://doi.org/10.1117/12.2183587
Event: European Conferences on Biomedical Optics, 2015, Munich, Germany

Abstract

We have engineered nano-vesicles, derived from erythrocytes, which can be doped with various near infrared (NIR) organic chromophores, including the FDA-approved indocyanine green (ICG). We refer to these vesicles as NIR erythrocyte-mimicking transducers (NETS) since in response to NIR photo-excitation they can generate heat or emit fluorescent light. Using biochemical methods based on reduction amination, we have functionalized the surface of NET with antibodies to target specific biomolecules. We present results that demonstrate the effectiveness of NETs in targeted imaging of cancer cells that over-express the human epidermal growth factor receptor-2 (HER2).

Citation Download Citation

Jenny T. Mac, Vicente Nunez, Baharak Bahmani, Yadir Guerrero, Jack Tang, Valentine I. Vullev, and Bahman Anvari "Erythrocyte-derived optical nano-vesicles as theranostic agents", Proc. SPIE 9540, Novel Biophotonics Techniques and Applications III, 95400H (13 July 2015); https://doi.org/10.1117/12.2183587

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KEYWORDS

Near infrared

Luminescence

Absorption

Chromophores

Cancer

Indocyanine green

Receptors

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