In-situ monitoring of blood glucose level for dialysis machine by AAA-battery-size ATR Fourier spectroscopy

Satsuki Hosono; Shun Sato; Akane Ishida; Yo Suzuki; Daichi Inohara; Kosuke Nogo; Pradeep K.W. Abeygunawardhana; Satoru Suzuki; Akira Nishiyama; Kenji Wada; Ichiro Ishimaru

doi:10.1117/12.2183674

15 July 2015 In-situ monitoring of blood glucose level for dialysis machine by AAA-battery-size ATR Fourier spectroscopy

Satsuki Hosono, Shun Sato, Akane Ishida, Yo Suzuki, Daichi Inohara, Kosuke Nogo, Pradeep K.W. Abeygunawardhana, Satoru Suzuki, Akira Nishiyama, Kenji Wada, Ichiro Ishimaru

Author Affiliations +

Proceedings Volume 9537, Clinical and Biomedical Spectroscopy and Imaging IV; 953715 (2015) https://doi.org/10.1117/12.2183674
Event: European Conferences on Biomedical Optics, 2015, Munich, Germany

Abstract

For blood glucose level measurement of dialysis machines, we proposed AAA-battery-size ATR (Attenuated total reflection) Fourier spectroscopy in middle infrared light region. The proposed one-shot Fourier spectroscopic imaging is a near-common path and spatial phase-shift interferometer with high time resolution. Because numerous number of spectral data that is 60 (= camera frame rare e.g. 60[Hz]) multiplied by pixel number could be obtained in 1[sec.], statistical-averaging improvement realize high-accurate spectral measurement. We evaluated the quantitative accuracy of our proposed method for measuring glucose concentration in near-infrared light region with liquid cells. We confirmed that absorbance at 1600[nm] had high correlations with glucose concentrations (correlation coefficient: 0.92). But to measure whole-blood, complex light phenomenon caused from red blood cells, that is scattering and multiple reflection or so, deteriorate spectral data. Thus, we also proposed the ultrasound-assisted spectroscopic imaging that traps particles at standing-wave node. Thus, if ATR prism is oscillated mechanically, anti-node area is generated around evanescent light field on prism surface. By elimination complex light phenomenon of red blood cells, glucose concentration in whole-blood will be quantify with high accuracy. In this report, we successfully trapped red blood cells in normal saline solution with ultrasonic standing wave (frequency: 2[MHz]).

Citation Download Citation

Satsuki Hosono, Shun Sato, Akane Ishida, Yo Suzuki, Daichi Inohara, Kosuke Nogo, Pradeep K.W. Abeygunawardhana, Satoru Suzuki, Akira Nishiyama, Kenji Wada, and Ichiro Ishimaru "In-situ monitoring of blood glucose level for dialysis machine by AAA-battery-size ATR Fourier spectroscopy", Proc. SPIE 9537, Clinical and Biomedical Spectroscopy and Imaging IV, 953715 (15 July 2015); https://doi.org/10.1117/12.2183674

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
4 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Blood

Glucose

Imaging spectroscopy

Fourier spectroscopy

Spectroscopy

Attenuated total reflectance

Liquids

Show All Keywords

Keywords/Phrases

Search In:

Publication Years