Liquid sensor based bio-chip for DNA analysis of cancer using photonic crystal

Harshada Patil; Nischitha R.; Indumathi T. S.; Preeta Sharan

doi:10.1117/12.2189606

17 July 2015 Liquid sensor based bio-chip for DNA analysis of cancer using photonic crystal

Harshada Patil, Nischitha R., Indumathi T. S., Preeta Sharan

Proceedings Volume 9524, International Conference on Optical and Photonic Engineering (icOPEN 2015); 95241Y (2015) https://doi.org/10.1117/12.2189606
Event: International Conference on Optical and Photonic Engineering (icOPEN2015), 2015, Singapore, Singapore

Abstract

Silicon photonics is poised to revolutionize bio-sensing applications, specifically in medical diagnostics. The need for cost effective and reliable bio-sensors in medical applications is an ever growing and everlasting one. In this synopsis we have designed a 2-D hexagonal photonic crystal ring resonator based bio-sensor that is able to detect lung cancer from blood. Simulation and analysis has been done for normal DNA and the cancer affected DNA in blood. The intensity level of transmission spectrum has been observed. Finite Difference Time Domain (FDTD) method is used for analysis. MEEP (MIT Electromagnetic Equation Propagation) tool and RSOFT Photonic Suite CAD tool are used designing the photonic crystal sensor. The results show that for small changes in the refractive index of the input samples there is a significant shift in wavelength and amplitude. Thus the sensor is highly sensitive for change in refractive index and hence differentiating normal and cancer affected DNA.

Citation Download Citation

Harshada Patil, Nischitha R., Indumathi T. S., and Preeta Sharan "Liquid sensor based bio-chip for DNA analysis of cancer using photonic crystal", Proc. SPIE 9524, International Conference on Optical and Photonic Engineering (icOPEN 2015), 95241Y (17 July 2015); https://doi.org/10.1117/12.2189606

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KEYWORDS

Photonic crystals

Lung cancer

Cancer

Sensors

Magnetism

Computer aided design

Refractive index

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