Optical frequency domain imaging with a rapidly swept laser in the 1300nm bio-imaging window

Ratheesh Kumar Meleppat; Murukeshan Vadakke Matham; Leong Keey Seah

doi:10.1117/12.2190530

17 July 2015 Optical frequency domain imaging with a rapidly swept laser in the 1300nm bio-imaging window

Ratheesh Kumar Meleppat, Murukeshan Vadakke Matham, Leong Keey Seah

Proceedings Volume 9524, International Conference on Optical and Photonic Engineering (icOPEN 2015); 95242R (2015) https://doi.org/10.1117/12.2190530
Event: International Conference on Optical and Photonic Engineering (icOPEN2015), 2015, Singapore, Singapore

Abstract

Optical frequency domain imaging system (OFDI) in the 1300nm biological imaging window is demonstrated by using a high speed frequency swept laser source. The output of the laser with central wave length of 1320nm is continuously tuned over a bandwidth of 100nm with a repetition rate of 16 KHz. The laser source has an instantaneous coherence length of 6mm and delivers an average power of 12mW. Axial resolution ~ 6μm in the biological tissue and peak sensitivity of 110dB are achieved. The experimentally determined values of the imaging parameters such as the axial resolution, sensitivity and depth range are found to be in good agreement with the theoretically estimated values. The developed system is capable of generating the images of size 512x1024 at a rate of 20 frames per second. High resolution and high contrast images of the finger nail and anterior chamber of a pig’s eye acquired using the developed OFDI system are presented, which demonstrate the feasibility of the system for in-vivo biomedical imaging applications.

Citation Download Citation

Ratheesh Kumar Meleppat, Murukeshan Vadakke Matham, and Leong Keey Seah "Optical frequency domain imaging with a rapidly swept laser in the 1300nm bio-imaging window", Proc. SPIE 9524, International Conference on Optical and Photonic Engineering (icOPEN 2015), 95242R (17 July 2015); https://doi.org/10.1117/12.2190530

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available