Integrated multi-color illumination source for lab-on-a-chip fluorescence analysis

Abdullah J. Zakariya; Eshaq Mulla

doi:10.1117/12.2187275

28 August 2015 Integrated multi-color illumination source for lab-on-a-chip fluorescence analysis

Abdullah J. Zakariya, Eshaq Mulla

Proceedings Volume 9609, Infrared Sensors, Devices, and Applications V; 96090R (2015) https://doi.org/10.1117/12.2187275
Event: SPIE Optical Engineering + Applications, 2015, San Diego, California, United States

Abstract

We propose an integrated microfluidic optical system device design for a monolithic integration of blood plasma analysis in a single step using microfluidic channels on a tri wavelength LED source emitting wavelengths in ultraviolet, infrared and visible. The device is a miniature disposable Lab-on-a-Chip as small as 6x 1.5mm with a blood plasma reservoir volume of 2μl providing instantaneous results. The device is fabricated using minimal lithographic fabrication steps and consists of a microfluidic Polydimethylsiloxane (PDMS) layer on top of a quantum well (QW) structure. The PDMS layer has three 100μm thick microfluidic channels connected to the 2μl reservoir where the blood plasma is injected. The three microfluidic channels pass over the QW substrate which is micro fabricated to produce three LEDs that emit light in three different wavelengths on a single structure. The LEDs emit light in UV, infrared and visible and can be controlled individually for specific plasma testing or can emit light simultaneously depending on the application. To operate the device, first current is injected into the LEDs to turn on light emission. Light travels within the LED structure and at the same time light is emitted through the surface. Light can be either collected from the top of the device or the output facets by focusing the channels output on a spectrometer to collect the spectra of the device and analyze the output. The device is compact in size and provides fast, low power consumption and cost effective point of care devices with minimal heat output.

Citation Download Citation

Abdullah J. Zakariya and Eshaq Mulla "Integrated multi-color illumination source for lab-on-a-chip fluorescence analysis", Proc. SPIE 9609, Infrared Sensors, Devices, and Applications V, 96090R (28 August 2015); https://doi.org/10.1117/12.2187275

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KEYWORDS

Light emitting diodes

Quantum wells

Blood

Lab on a chip

Microfluidics

Plasma

Point-of-care devices

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