Characterization of atherosclerotic plaques by cross-polarization optical coherence tomography

Ekaterina V. Gubarkova; Varvara V. Dudenkova; Felix I. Feldchtein; Lidia B. Timofeeva; Elena B. Kiseleva; Sergei S. Kuznetsov M.D.; Alexander A. Moiseev; Gregory V. Gelikonov; Alex I. Vitkin; Natalia D. Gladkova

doi:10.1117/12.2210822

29 February 2016 Characterization of atherosclerotic plaques by cross-polarization optical coherence tomography

Ekaterina V. Gubarkova, Varvara V. Dudenkova, Felix I. Feldchtein, Lidia B. Timofeeva, Elena B. Kiseleva, Sergei S. Kuznetsov M.D., Alexander A. Moiseev, Gregory V. Gelikonov, Alex I. Vitkin, Natalia D. Gladkova

Author Affiliations +

Proceedings Volume 9689, Photonic Therapeutics and Diagnostics XII; 96893F (2016) https://doi.org/10.1117/12.2210822
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

We combined cross-polarization optical coherence tomography (CP OCT) and non-linear microscopy based on second harmonic generation (SHG) and two-photon-excited fluorescence (2PEF) to assess collagen and elastin fibers in the development of the atherosclerotic plaque (AP). The study shows potential of CP OCT for the assessment of collagen and elastin fibers condition in atherosclerotic arteries. Specifically, the additional information afforded by CP OCT, related to birefringence and cross-scattering properties of arterial tissues, may improve the robustness and accuracy of assessment about the microstructure and composition of the plaque for different stages of atherosclerosis.

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Ekaterina V. Gubarkova, Varvara V. Dudenkova, Felix I. Feldchtein, Lidia B. Timofeeva, Elena B. Kiseleva, Sergei S. Kuznetsov M.D., Alexander A. Moiseev, Gregory V. Gelikonov, Alex I. Vitkin, and Natalia D. Gladkova "Characterization of atherosclerotic plaques by cross-polarization optical coherence tomography", Proc. SPIE 9689, Photonic Therapeutics and Diagnostics XII, 96893F (29 February 2016); https://doi.org/10.1117/12.2210822

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