Morphologic 3D scanning of fallopian tubes to assist ovarian cancer diagnosis

Wendy-Julie Madore; Etienne De Montigny; Andréanne Deschênes; Fouzi Benboujja; Mikael Leduc; Anne-Marie Mes-Masson; Diane M. Provencher M.D.; Kurosh Rahimi M.D.; Caroline Boudoux; Nicolas Godbout

doi:10.1117/12.2211204

29 February 2016 Morphologic 3D scanning of fallopian tubes to assist ovarian cancer diagnosis

Wendy-Julie Madore, Etienne De Montigny, Andréanne Deschênes, Fouzi Benboujja, Mikael Leduc, Anne-Marie Mes-Masson, Diane M. Provencher M.D., Kurosh Rahimi M.D., Caroline Boudoux, Nicolas Godbout

Author Affiliations +

Proceedings Volume 9689, Photonic Therapeutics and Diagnostics XII; 96894D (2016) https://doi.org/10.1117/12.2211204
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Pathological evaluation of the fallopian tubes is an important diagnostic result but tumors can be missed using routine approaches. As the majority of high-grade serous ovarian cancers are now believed to originate in the fallopian tubes, pathological examination should include in a thorough examination of the excised ovaries and fallopian tubes. We present an dedicated imaging system for diagnostic exploration of human fallopian tubes. This system is based on optical coherence tomography (OCT), a laser imaging modality giving access to sub- epithelial tissue architecture. This system produces cross-sectional images up to 3 mm in depth, with a lateral resolution of ≈15μm and an axial resolution of ≈12μm. An endoscopic single fiber probe was developed to fit in a human fallopian tube. This 1.2 mm probe produces 3D volume data of the entire inner tube within a few minutes. To demonstrate the clinical potential of OCT for lesion identification, we studied 5 different ovarian lesions and healthy fallopian tubes. We imaged 52 paraffin-embedded human surgical specimens with a benchtop system and compared these images with histology slides. We also imaged and compared healthy oviducts from 3 animal models to find one resembling the human anatomy and to develop a functional ex vivo imaging procedure with the endoscopic probe. We also present an update on an ongoing clinical pilot study on women undergoing prophylactic or diagnostic surgery in which we image ex vivo fallopian tubes with the endoscopic probe.

Citation Download Citation

Wendy-Julie Madore, Etienne De Montigny, Andréanne Deschênes, Fouzi Benboujja, Mikael Leduc, Anne-Marie Mes-Masson, Diane M. Provencher M.D., Kurosh Rahimi M.D., Caroline Boudoux, and Nicolas Godbout "Morphologic 3D scanning of fallopian tubes to assist ovarian cancer diagnosis", Proc. SPIE 9689, Photonic Therapeutics and Diagnostics XII, 96894D (29 February 2016); https://doi.org/10.1117/12.2211204

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available