Non-invasive assessment of cerebral microcirculation with diffuse optics and coherent hemodynamics spectroscopy

Sergio Fantini; Angelo Sassaroli; Jana M. Kainerstorfer; Kristen T. Tgavalekos; Xuan Zang

doi:10.1117/12.2213139

9 March 2016 Non-invasive assessment of cerebral microcirculation with diffuse optics and coherent hemodynamics spectroscopy

Sergio Fantini, Angelo Sassaroli, Jana M. Kainerstorfer, Kristen T. Tgavalekos, Xuan Zang

Author Affiliations +

Proceedings Volume 9690, Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation; 96900S (2016) https://doi.org/10.1117/12.2213139
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

We describe the general principles and initial results of coherent hemodynamics spectroscopy (CHS), which is a new technique for the quantitative assessment of cerebral hemodynamics on the basis of dynamic near-infrared spectroscopy (NIRS) measurements. The two components of CHS are (1) dynamic measurements of coherent cerebral hemodynamics in the form of oscillations at multiple frequencies (frequency domain) or temporal transients (time domain), and (2) their quantitative analysis with a dynamic mathematical model that relates the concentration and oxygen saturation of hemoglobin in tissue to cerebral blood volume (CBV), cerebral blood flow (CBF), and cerebral metabolic rate of oxygen (CMRO2). In particular, CHS can provide absolute measurements and dynamic monitoring of CBF, and quantitative measures of cerebral autoregulation. We report initial results of CBF measurements in hemodialysis patients, where we found a lower CBF (54 ± 16 ml/(100 g-min)) compared to a group of healthy controls (95 ± 11 ml/(100 g-min)). We also report CHS measurements of cerebral autoregulation, where a quantitative index of autoregulation (its cutoff frequency) was found to be significantly greater in healthy subjects during hyperventilation (0.034 ± 0.005 Hz) than during normal breathing (0.017 ± 0.002 Hz). We also present our approach to depth resolved CHS, based on multi-distance, frequency-domain NIRS data and a two-layer diffusion model, to enhance sensitivity to cerebral tissue. CHS offers a potentially powerful approach to the quantitative assessment and continuous monitoring of local brain perfusion at the microcirculation level, with prospective brain mapping capabilities of research and clinical significance.

Conference Presentation

Citation Download Citation

Sergio Fantini, Angelo Sassaroli, Jana M. Kainerstorfer, Kristen T. Tgavalekos, and Xuan Zang "Non-invasive assessment of cerebral microcirculation with diffuse optics and coherent hemodynamics spectroscopy", Proc. SPIE 9690, Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation, 96900S (9 March 2016); https://doi.org/10.1117/12.2213139

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available